Fentanyl transdermal system and Zide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Fentanyl transdermal system (fentanyl) and Zide (hydrochlorothiazide). Common drug interactions include application site erythema among females and dyspnoea among males.

The phase IV clinical study analyzes what interactions people have when they take Fentanyl transdermal system and Zide. It is created by eHealthMe based on reports of 100 people who take the same drugs from the FDA, and is updated regularly.

What is Fentanyl transdermal system?

Fentanyl transdermal system has active ingredients of fentanyl. It is often used in pain. eHealthMe is studying from 5,728 Fentanyl transdermal system users. Check the latest studies of Fentanyl transdermal system.

What is Zide?

Zide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 183,246 Zide users. Check the latest studies of Zide.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

100 people who take Fentanyl transdermal system and Zide together, and have interactions are studied.

Fentanyl transdermal system and Zide drug interactions.

What are the common drug interactions of Fentanyl Transdermal System and Zide, by gender? *:

female:

Application site erythema (redness of the skin at application site)
Application site pruritus (application site severe itching of the skin)
Hyperhidrosis (abnormally increased sweating)
Death
Muscle twitching
Rash
Fatigue (feeling of tiredness)
Somnolence (a state of near-sleep, a strong desire for sleep)
Tremor (trembling or shaking movements in one or more parts of your body)
Unresponsive to stimuli

male:

Dyspnoea (difficult or laboured respiration)
Drug ineffective
Therapeutic response decreased (less preventive response)
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Aspartate aminotransferase increased
Asthenia (weakness)
Breakthrough pain
Carotid artery occlusion (artery blockage)
Constipation
Dehydration (dryness resulting from the removal of water)

What are the common drug interactions of Fentanyl Transdermal System and Zide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Dizziness
Somnolence (a state of near-sleep, a strong desire for sleep)
Unresponsive to stimuli
Urine output decreased
Urinary retention (the inability to completely or partially empty the bladder)
Application site erythema (redness of the skin at application site)
Application site pruritus (application site severe itching of the skin)
Fatigue (feeling of tiredness)
Nausea (feeling of having an urge to vomit)
Overdose

50-59:

Drug effect decreased
Dyspnoea (difficult or laboured respiration)
Eyelid ptosis (falling of the upper or lower eyelid)
Fluid retention (an abnormal accumulation of fluid in the blood)
Gamma-glutamyltransferase increased
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Weight decreased
Weight increased
Drug effect increased

60+:

Dyspnoea (difficult or laboured respiration)
Insomnia (sleeplessness)
Asthenia (weakness)
Death
Drug dependence
Diarrhoea
Tremor (trembling or shaking movements in one or more parts of your body)
Abdominal pain
Fall
Hypersomnia (excessive daytime sleepiness (eds))

What are the existing conditions these people have? *

Back Pain: 33 people, 33.00%
High Blood Cholesterol: 20 people, 20.00%
Depression: 15 people, 15.00%
Fluid Retention (an abnormal accumulation of fluid in the blood): 15 people, 15.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 11 people, 11.00%
Joint Pain: 11 people, 11.00%
Sleep Disorder: 11 people, 11.00%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 10 people, 10.00%
Muscle Spasms (muscle contraction): 9 people, 9.00%
Breakthrough Pain: 8 people, 8.00%

* Approximation only. Some reports may have incomplete information.

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