Fentanyl and Chlor-trimeton drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Fentanyl (fentanyl citrate) and Chlor-trimeton (chlorpheniramine maleate). Common drug interactions include thrombosis among females and renal impairment among males.

The phase IV clinical study analyzes what interactions people have when they take Fentanyl and Chlor-trimeton. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Fentanyl?

Fentanyl has active ingredients of fentanyl citrate. It is often used in pain. eHealthMe is studying from 73,301 Fentanyl users. Check the latest studies of Fentanyl.

What is Chlor-trimeton?

Chlor-trimeton has active ingredients of chlorpheniramine maleate. It is often used in allergies. eHealthMe is studying from 1,472 Chlor-trimeton users. Check the latest studies of Chlor-trimeton.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 28, 2026

24 people who take Fentanyl and Chlor-trimeton together, and have interactions are studied.

Fentanyl and Chlor-trimeton drug interactions.

What are the common drug interactions of Fentanyl and Chlor-Trimeton, by gender? *:

female:

Thrombosis (formation of a blood clot inside a blood vessel)
Ventricular arrhythmia (problem with the rate or rhythm of the heartbeat)
Adenovirus infection
Diarrhoea
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Hyperglycaemia (high blood sugar)
Ileus paralytic (obstruction of the intestine due to paralysis of the intestinal muscles)
Pneumothorax (the presence of air or gas in the cavity between the lungs and the chest wall, causing collapse of the lung)
Respiratory disorder (respiratory disease)
Thrombotic microangiopathy (a pathology that results in thrombosis in capillaries and arterioles, due to an endothelial injury)

male:

Renal impairment (severely reduced kidney function)
Hypertension (high blood pressure)
Pyrexia (fever)
Asthma
Bacterial infection
Chest pain
Cough
Cystitis haemorrhagic (blood in the urine and painful voiding)
Cytomegalovirus viraemia (cytomegalo virus in blood stream)
Diarrhoea

What are the common drug interactions of Fentanyl and Chlor-Trimeton, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Cytomegalovirus viraemia (cytomegalo virus in blood stream)
Cytomegalovirus test positive
Stem cell transplant
Adenovirus infection
Diarrhoea
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Hyperglycaemia (high blood sugar)
Ileus paralytic (obstruction of the intestine due to paralysis of the intestinal muscles)
Pneumothorax (the presence of air or gas in the cavity between the lungs and the chest wall, causing collapse of the lung)
Respiratory disorder (respiratory disease)

20-29:

n/a

30-39:

Asthma
Bacterial infection
Chest pain
Cough
Cystitis haemorrhagic (blood in the urine and painful voiding)
Cytomegalovirus viraemia (cytomegalo virus in blood stream)
Diarrhoea
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Graft versus host disease in lung (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the lung)
Hypertension (high blood pressure)

40-49:

Pyrexia (fever)
Arthralgia (joint pain)
Ascites (accumulation of fluid in the abdominal cavity)
Aspartate aminotransferase increased
Atelectasis (partial or complete collapse of the lung)
Blood lactate dehydrogenase increased
Blood phosphorus increased
Blood sodium decreased
Dysarthria (speech disorder)
Erythema (redness of the skin)

50-59:

n/a

60+:

Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Death
Platelet count decreased
Sepsis (a severe blood infection that can lead to organ failure and death)
Blood albumin decreased
Blood glucose increased
Colorectal cancer (colon cancer or bowel cancer)
Decubitus ulcer (a chronic ulcer of the skin caused by prolonged pressure on it)
Febrile neutropenia (fever with reduced white blood cells)
Hyperammonaemia

What are the existing conditions these people have? *

Renal Impairment (severely reduced kidney function): 6 people, 25.00%
High Blood Pressure: 6 people, 25.00%
Multiple Myeloma (cancer of the plasma cells): 6 people, 25.00%
Abnormal Clotting Factor: 5 people, 20.83%
Ileus Paralytic (obstruction of the intestine due to paralysis of the intestinal muscles): 5 people, 20.83%
Generalised Oedema (swelling all over the body): 5 people, 20.83%
Graft Versus Host Disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body): 5 people, 20.83%
Hyperglycemia (high blood sugar): 5 people, 20.83%
Hypoalbuminaemia (levels of albumin in blood serum are abnormally low): 5 people, 20.83%
Sepsis (a severe blood infection that can lead to organ failure and death): 5 people, 20.83%

* Approximation only. Some reports may have incomplete information.

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