Fentanyl and Hydroxyurea drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Fentanyl (fentanyl citrate) and Hydroxyurea (hydroxyurea). Common drug interactions include paraneoplastic syndrome among females and dehydration among males.

The phase IV clinical study analyzes what interactions people have when they take Fentanyl and Hydroxyurea. It is created by eHealthMe based on reports of 66 people who take the same drugs from the FDA, and is updated regularly.

What is Fentanyl?

Fentanyl has active ingredients of fentanyl citrate. It is often used in pain. eHealthMe is studying from 73,301 Fentanyl users. Check the latest studies of Fentanyl.

What is Hydroxyurea?

Hydroxyurea has active ingredients of hydroxyurea. It is often used in polycythemia vera. eHealthMe is studying from 17,240 Hydroxyurea users. Check the latest studies of Hydroxyurea.

On Jul, 14, 2026

66 people who take Fentanyl and Hydroxyurea together, and have interactions are studied.

Fentanyl and Hydroxyurea drug interactions.

What are the common drug interactions of Fentanyl and Hydroxyurea, by gender? *:

female:

Paraneoplastic syndrome (symptom that is the consequence of the presence of cancer in the body)
Abasia (inability to walk)
Abdominal pain
Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
Asthenia (weakness)
Drug ineffective
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Haematemesis (vomiting of blood)
Headache (pain in head)
Hypotension (abnormally low blood pressure)

male:

Dehydration (dryness resulting from the removal of water)
Nausea (feeling of having an urge to vomit)
Pain in extremity
Sepsis (a severe blood infection that can lead to organ failure and death)
Blood creatinine increased
Death
Lethargy (tiredness)
Abdominal distension
Acute lymphocytic leukaemia recurrent (cancer in which the bone marrow makes too many lymphocytes-recurrent)
Aspergillus test positive

What are the common drug interactions of Fentanyl and Hydroxyurea, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Cough
Pyrexia (fever)
Paraneoplastic syndrome (symptom that is the consequence of the presence of cancer in the body)
Abdominal distension
Acute lymphocytic leukaemia recurrent (cancer in which the bone marrow makes too many lymphocytes-recurrent)
Aspergillus test positive
Bacteraemia (presence of bacteria in the blood)
Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)
C-reactive protein increased
Central nervous system lesion (an abnormality in tissue of brain or spinal cord)

20-29:

Haemoglobin decreased
White blood cell count increased
Anaemia (lack of blood)
Asthenia (weakness)
Dizziness
Haematocrit decreased
Lymphocyte count decreased
Mean cell volume decreased (less of the average red blood cell volume)
Monocyte count increased
Nausea (feeling of having an urge to vomit)

30-39:

Anaemia (lack of blood)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Splenic infarction (tissue damage of spleen)
Tumour lysis syndrome (a group of metabolic complications that can occur after treatment of cancer, these complications are caused by the breakdown products of dying cancer cells)
Abdominal pain
Drug ineffective
Nausea (feeling of having an urge to vomit)
Sepsis (a severe blood infection that can lead to organ failure and death)
Vomiting

40-49:

Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)
Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
Acute myeloid leukaemia recurrent (acute cancer in which the bone marrow makes abnormal myeloblast- recurrent)
Application site rash
Coma (state of unconsciousness lasting more than six hours)
Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
Grunting (abnormal, short, deep, hoarse sounds in exhalation that often accompany severe chest pain)
Neoplasm progression (growth of tumour)
Pneumonia klebsiella (pneumonia caused by bacteria klebsiella)
Rash macular (small, flat red spots)

50-59:

Abdominal pain upper
Bladder cyst
Blood urine present
Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)
Cardiac arrest
Chest discomfort
Deafness bilateral
Death
Depressed level of consciousness
Depression

60+:

Arthralgia (joint pain)
Pain in extremity
Diarrhoea
General physical health deterioration (weak health status)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Vomiting
Dehydration (dryness resulting from the removal of water)
Abasia (inability to walk)
Abdominal pain
Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)

What are the existing conditions these people have? *

Nausea (feeling of having an urge to vomit): 9 people, 13.64%
Constipation: 9 people, 13.64%
Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 8 people, 12.12%
Headache (pain in head): 7 people, 10.61%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 7 people, 10.61%
Squamous Cell Carcinoma (a cancer of a kind of epithelial cell): 6 people, 9.09%
Nausea And Vomiting: 6 people, 9.09%
Hypersensitivity: 6 people, 9.09%
Primary Myelofibrosis (primary disorder of the bone marrow): 5 people, 7.58%
Insomnia (sleeplessness): 5 people, 7.58%

* Approximation only. Some reports may have incomplete information.

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