Fentanyl and Kyprolis drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Fentanyl (fentanyl citrate) and Kyprolis (carfilzomib). Common drug interactions include blood potassium increased among females and thrombocytopenia among males.

The phase IV clinical study analyzes what interactions people have when they take Fentanyl and Kyprolis. It is created by eHealthMe based on reports of 83 people who take the same drugs from the FDA, and is updated regularly.

What is Fentanyl?

Fentanyl has active ingredients of fentanyl citrate. It is often used in pain. eHealthMe is studying from 73,301 Fentanyl users. Check the latest studies of Fentanyl.

What is Kyprolis?

Kyprolis has active ingredients of carfilzomib. It is often used in multiple myeloma. eHealthMe is studying from 15,080 Kyprolis users. Check the latest studies of Kyprolis.

On Jul, 20, 2026

83 people who take Fentanyl and Kyprolis together, and have interactions are studied.

Fentanyl and Kyprolis drug interactions.

What are the common drug interactions of Fentanyl and Kyprolis, by gender? *:

female:

Blood potassium increased
Cardiac disorder
Chest pain
Cholangiocarcinoma (a cancer that forms glands or secretes significant amounts of mucins)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Depression
Disease progression
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Eye infection
Failure to thrive (inadequate weight gain and physical growth in children)

male:

Thrombocytopenia (decrease of platelets in blood)
Lymphopenia (an abnormally low level of lymphocytes in the blood)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Death
Nasopharyngitis (inflammation of the nasopharynx)
Platelet count decreased
White blood cell count decreased
Drug ineffective
C-reactive protein increased
Chronic kidney disease

What are the common drug interactions of Fentanyl and Kyprolis, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Fatigue (feeling of tiredness)
Hypersomnia (excessive daytime sleepiness (eds))
Nausea (feeling of having an urge to vomit)
Vomiting

50-59:

Pulmonary embolism (blockage of the main artery of the lung)
Thrombocytopenia (decrease of platelets in blood)
Hypersomnia (excessive daytime sleepiness (eds))
Abdominal distension
Bone pain
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Constipation
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Dyspnoea (difficult or laboured respiration)

60+:

Thrombocytopenia (decrease of platelets in blood)
Lymphopenia (an abnormally low level of lymphocytes in the blood)
Nasopharyngitis (inflammation of the nasopharynx)
Platelet count decreased
White blood cell count decreased
Asthenia (weakness)
C-reactive protein increased
Death
Decreased appetite
Nausea (feeling of having an urge to vomit)

What are the existing conditions these people have? *

Constipation: 16 people, 19.28%
Osteolysis (dissolution of bone): 12 people, 14.46%
Joint Pain: 12 people, 14.46%
Nausea (feeling of having an urge to vomit): 6 people, 7.23%
Bone Disorder: 5 people, 6.02%

* Approximation only. Some reports may have incomplete information.

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