Fentanyl and Lamivudine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Fentanyl (fentanyl citrate) and Lamivudine (lamivudine; zidovudine; nevirapine). Common drug interactions include diarrhoea among females and ascites among males.

The phase IV clinical study analyzes what interactions people have when they take Fentanyl and Lamivudine. It is created by eHealthMe based on reports of 60 people who take the same drugs from the FDA, and is updated regularly.

What is Fentanyl?

Fentanyl has active ingredients of fentanyl citrate. It is often used in pain. eHealthMe is studying from 73,301 Fentanyl users. Check the latest studies of Fentanyl.

What is Lamivudine?

Lamivudine has active ingredients of lamivudine; zidovudine; nevirapine. It is often used in hiv infection. eHealthMe is studying from 17,242 Lamivudine users. Check the latest studies of Lamivudine.



On Aug, 11, 2026

60 people who take Fentanyl and Lamivudine together, and have interactions are studied.

Fentanyl and Lamivudine drug interactions.

What are the common drug interactions of Fentanyl and Lamivudine, by gender? *:

female:

  1. Diarrhoea
  2. Malaise (a feeling of general discomfort or uneasiness)
  3. Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
  4. Nausea (feeling of having an urge to vomit)
  5. Otitis media (inflammation of the middle ear)
  6. Renal failure acute (rapid kidney dysfunction)
  7. Rigors (an episode of shaking or exaggerated shivering)
  8. Sepsis (a severe blood infection that can lead to organ failure and death)
  9. Anaemia (lack of blood)
  10. Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)

male:

  1. Ascites (accumulation of fluid in the abdominal cavity)
  2. Pyrexia (fever)
  3. Narcolepsy (brain's inability to regulate sleep-wake cycles normally)
  4. Pleural effusion (water on the lungs)
  5. Somnambulism (sleep walking)
  6. Somnolence (a state of near-sleep, a strong desire for sleep)
  7. Confusional state
  8. Gastroenteritis cryptosporidial (inflammation of stomach and intestine caused by cryptosporidial infection)
  9. Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
  10. Sepsis (a severe blood infection that can lead to organ failure and death)

What are the common drug interactions of Fentanyl and Lamivudine, by age (0-1 to 60+)? *:

0-1:

  1. Anaemia (lack of blood)
  2. Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
  3. Blood creatinine increased
  4. Blood urea increased
  5. Decreased activity
  6. Dehydration (dryness resulting from the removal of water)
  7. Electrolyte imbalance
  8. Haemolysis (breaking open of red blood cells and the release of haemoglobin into the surrounding fluid)
  9. Hypotension (abnormally low blood pressure)
  10. Irritability

2-9:

n/a

10-19:

  1. Aphasia (damage to the parts of the brain that control language)
  2. Asthenia (weakness)
  3. Paralysis

20-29:

n/a

30-39:

  1. Myalgia (muscle pain)
  2. Nausea (feeling of having an urge to vomit)
  3. Rhinorrhoea (watery mucus discharge from the nose)
  4. Viral infection
  5. Vomiting
  6. Abdominal pain
  7. Appetite decreased (decreased appetite occurs when you have a reduced desire to eat)
  8. Diarrhoea
  9. Malaise (a feeling of general discomfort or uneasiness)
  10. Rigors (an episode of shaking or exaggerated shivering)

40-49:

  1. Ascites (accumulation of fluid in the abdominal cavity)
  2. Pleural effusion (water on the lungs)
  3. Asthenia (weakness)
  4. Cholangitis (infection of the bile duct)
  5. Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
  6. Carcinoma (cancer)
  7. Hoarseness (changing voice)
  8. Hypoglycaemia (deficiency of glucose in the bloodstream)
  9. Insomnia (sleeplessness)
  10. Loss of consciousness

50-59:

  1. Hypoaesthesia (reduced sense of touch or sensation)
  2. Hypoxia (low oxygen in tissues)
  3. Pyrexia (fever)
  4. Abdominal distension
  5. Alanine aminotransferase increased
  6. Aspartate aminotransferase increased
  7. Blood lactate dehydrogenase increased
  8. Bradycardia (abnormally slow heart action)
  9. Diarrhoea
  10. Muscular weakness (muscle weakness)

60+:

  1. Dyspnoea (difficult or laboured respiration)
  2. Ascites (accumulation of fluid in the abdominal cavity)
  3. Thrombocytopenia (decrease of platelets in blood)
  4. Acute respiratory distress syndrome
  5. Blood creatinine increased
  6. Bone marrow failure
  7. Candiduria (candida in urine)
  8. Cardiac failure
  9. Cheilitis (infection of lips)
  10. Constipation

What are the existing conditions these people have? *

  1. Hepatic Neoplasm Malignant (liver cancer): 11 people, 18.33%
  2. Diarrhea: 10 people, 16.67%
  3. Hepatitis (inflammation of the liver): 9 people, 15.00%
  4. Abdominal Pain: 7 people, 11.67%
  5. Nausea And Vomiting: 5 people, 8.33%
  6. Multiple Myeloma (cancer of the plasma cells): 5 people, 8.33%
  7. Lung Disorder (lung disease): 5 people, 8.33%
  8. Gastroenteritis Cryptosporidial (inflammation of stomach and intestine caused by cryptosporidial infection): 5 people, 8.33%
  9. Dehydration (dryness resulting from the removal of water): 5 people, 8.33%
  10. Palmar-Plantar Erythrodysaesthesia Syndrome (hand-foot syndrome): 4 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Fentanyl and Lamivudine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Fentanyl:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Lamivudine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Fentanyl and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Lamivudine and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on fentanyl citrate and lamivudine; zidovudine; nevirapine (the active ingredients of Fentanyl and Lamivudine, respectively), and Fentanyl and Lamivudine (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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