Fentanyl and Nicorette drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Fentanyl (fentanyl citrate) and Nicorette (nicotine polacrilex). Common drug interactions include heart rate increased among females and atrial flutter among males.

The phase IV clinical study analyzes what interactions people have when they take Fentanyl and Nicorette. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Fentanyl?

Fentanyl has active ingredients of fentanyl citrate. It is often used in pain. eHealthMe is studying from 73,301 Fentanyl users. Check the latest studies of Fentanyl.

What is Nicorette?

Nicorette has active ingredients of nicotine polacrilex. It is often used in quit smoking. eHealthMe is studying from 18,484 Nicorette users. Check the latest studies of Nicorette.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

16 people who take Fentanyl and Nicorette together, and have interactions are studied.

Fentanyl and Nicorette drug interactions.

What are the common drug interactions of Fentanyl and Nicorette, by gender? *:

female:

Heart rate increased
Abdominal compartment syndrome (increased pressure in abdomen)
Abnormal sensation in eye
Acute respiratory distress syndrome
Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
Bacterial infection
Benign intracranial hypertension (benign intracranial hypertension (bih) is a headache syndrome)
Blood pressure increased
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Clostridium colitis (inflammation of colon by clostridium difficile bacteria infection)

male:

Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
Renal failure (kidney dysfunction)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Multi-organ failure (multisystem organ failure)
Septic shock (shock due to blood infection)
Supraventricular tachycardia (rapid heart rhythm originating at or above the atrioventricular node)
Acute respiratory distress syndrome
Hepatic congestion (liver congestion)
Hypoxia (low oxygen in tissues)
Pyrexia (fever)

What are the common drug interactions of Fentanyl and Nicorette, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Renal failure (kidney dysfunction)
Abdominal compartment syndrome (increased pressure in abdomen)
Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
Bacterial infection
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Gastric ulcer (stomach ulcer)
Haemodynamic instability (disturbances in the blood movement in our body)
Hepatic failure (liver failure)
Klebsiella bacteraemia (klebsiella bacteria in blood after infection to lungs)
Lactic acidosis (low ph in body tissues)

30-39:

n/a

40-49:

Abnormal sensation in eye
Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
Blood pressure increased
Collagen disorder (infection and weakness of collagen)
Drug ineffective
Dyspepsia (indigestion)
Fatigue (feeling of tiredness)
Food craving
Heart rate increased
Insomnia (sleeplessness)

50-59:

n/a

60+:

Abdominal compartment syndrome (increased pressure in abdomen)
Acute respiratory distress syndrome
Hepatic congestion (liver congestion)
Hepatic failure (liver failure)
Hypertension (high blood pressure)
Hypoxia (low oxygen in tissues)
Influenza virus test positive
Klebsiella bacteraemia (klebsiella bacteria in blood after infection to lungs)
Lactic acidosis (low ph in body tissues)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)

What are the existing conditions these people have? *

Insomnia (sleeplessness): 4 people, 25.00%
Dizziness: 2 people, 12.50%
Stress And Anxiety: 2 people, 12.50%
Type 2 Diabetes: 1 person, 6.25%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 6.25%
Birth Control: 1 person, 6.25%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 1 person, 6.25%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 1 person, 6.25%
Depression: 1 person, 6.25%
Diarrhea: 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

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