Fentanyl and Optimark drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Fentanyl (fentanyl citrate) and Optimark (gadoversetamide). Common drug interactions include skin burning sensation among females and nephrogenic systemic fibrosis among males.

The phase IV clinical study analyzes what interactions people have when they take Fentanyl and Optimark. It is created by eHealthMe based on reports of 27 people who take the same drugs from the FDA, and is updated regularly.

What is Fentanyl?

Fentanyl has active ingredients of fentanyl citrate. It is often used in pain. eHealthMe is studying from 73,301 Fentanyl users. Check the latest studies of Fentanyl.

What is Optimark?

Optimark has active ingredients of gadoversetamide. eHealthMe is studying from 3,055 Optimark users. Check the latest studies of Optimark.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

27 people who take Fentanyl and Optimark together, and have interactions are studied.

Fentanyl and Optimark drug interactions.

What are the common drug interactions of Fentanyl and Optimark, by gender? *:

female:

Skin burning sensation
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Scar
Ulcer
Depression
Gait disturbance
Injury
Limb discomfort (discomfort in leg)
Asthenia (weakness)
Cholecystitis acute (rapid infection of gallbladder)

male:

Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Skin hypertrophy (skin cells enlarges)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Arthralgia (joint pain)
Depression
Dry skin
Hypoaesthesia (reduced sense of touch or sensation)
Insomnia (sleeplessness)
Pain of skin
Skin atrophy (wasting of skin)

What are the common drug interactions of Fentanyl and Optimark, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Skin tightness
Dry skin
Extremity contracture (permanent shortening of a muscle or joint of arms and legs)
Hyperkeratosis (thickening of the outer layer of the skin)
Mobility decreased (ability to move is reduced)
Oedema (fluid collection in tissue)
Peripheral ischaemia (impaired circulation to an extremity)
Peroneal nerve palsy
Skin depigmentation (lightening of the skin)

30-39:

Weight decreased
Deformity (disfigurement)
Discomfort
Emotional disorder
Extremity contracture (permanent shortening of a muscle or joint of arms and legs)
Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
General physical health deterioration (weak health status)
Hyperkeratosis (thickening of the outer layer of the skin)
Joint contracture (a permanent shortening of a muscle or joint)
Muscle contracture (a permanent shortening of a muscle)

40-49:

Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Skin hypertrophy (skin cells enlarges)
Oedema peripheral (superficial swelling)
Skin induration (an abnormally hard spot or area on the skin)
Joint contracture (a permanent shortening of a muscle or joint)
Skin fibrosis (fibrous tissue formation on skin)
Skin ulcer
Deformity (disfigurement)
Extremity contracture (permanent shortening of a muscle or joint of arms and legs)
Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)

50-59:

Emotional distress
Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
Erythema (redness of the skin)
Oedema peripheral (superficial swelling)
Pain in extremity
Peau d'orange (orange peel skin)
Pruritus (severe itching of the skin)
Rash
Skin discolouration (change of skin colour)
Skin exfoliation (removal of the oldest dead skin cells)

60+:

Deformity (disfigurement)
Erythema (redness of the skin)
General physical health deterioration (weak health status)
Hypoaesthesia (reduced sense of touch or sensation)
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Oedema peripheral (superficial swelling)
Pain in extremity
Scar
Skin lesion

What are the existing conditions these people have? *

Nuclear Magnetic Resonance Imaging Brain: 11 people, 40.74%
Wound Complication: 4 people, 14.81%
Stress And Anxiety: 4 people, 14.81%
Nuclear Magnetic Resonance Imaging Abdominal: 4 people, 14.81%
Neuralgia (pain in one or more nerves): 4 people, 14.81%
Insomnia (sleeplessness): 4 people, 14.81%
Vasospasm (sudden constriction of a blood vessel, reducing its diameter and flow rate): 3 people, 11.11%
High Blood Pressure: 2 people, 7.41%

* Approximation only. Some reports may have incomplete information.

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