Fentanyl and Phytomenadione drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Fentanyl (fentanyl citrate) and Phytomenadione (vitamin k). Common drug interactions include methaemoglobinaemia among females and toxic epidermal necrolysis among males.

The phase IV clinical study analyzes what interactions people have when they take Fentanyl and Phytomenadione. It is created by eHealthMe based on reports of 26 people who take the same drugs from the FDA, and is updated regularly.

What is Fentanyl?

Fentanyl has active ingredients of fentanyl citrate. It is often used in pain. eHealthMe is studying from 73,301 Fentanyl users. Check the latest studies of Fentanyl.

What is Phytomenadione?

Phytomenadione has active ingredients of vitamin k. eHealthMe is studying from 924 Phytomenadione users. Check the latest studies of Phytomenadione.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 22, 2026

26 people who take Fentanyl and Phytomenadione together, and have interactions are studied.

Fentanyl and Phytomenadione drug interactions.

What are the common drug interactions of Fentanyl and Phytomenadione, by gender? *:

female:

Methaemoglobinaemia (a disorder characterized by the presence of a higher than normal level of methemoglobin in blood)
Microangiopathic haemolytic anaemia (anaemia due to inability of bone marrow to compensate the premature destruction of red blood cells)
Musculoskeletal discomfort (discomfort in the body's muscles, joints, tendons, ligaments and nerves)
Neutropenia (an abnormally low number of neutrophils)
Oropharyngeal pain
Palpitations (feelings or sensations that your heart is pounding or racing)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Peritoneal haemorrhage (peritoneal bleeding)
Platelet disorder
Pleural effusion (water on the lungs)

male:

Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)
Agitation (state of anxiety or nervous excitement)
Contusion (a type of hematoma of tissue in which capillaries)
General physical health deterioration (weak health status)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Mucosal inflammation (infection of mucous membrane)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Pneumonia
Pneumonitis (inflammation of the walls of the alveoli in the lungs)
Pulmonary haemorrhage (acute bleeding from the lung)

What are the common drug interactions of Fentanyl and Phytomenadione, by age (0-1 to 60+)? *:

0-1:

Pulmonary haemorrhage (acute bleeding from the lung)
Intraventricular haemorrhage (intraventricular bleeding)
Methaemoglobinaemia (a disorder characterized by the presence of a higher than normal level of methemoglobin in blood)
Pulmonary alveolar haemorrhage (acute bleeding)
Respiratory failure (inadequate gas exchange by the respiratory system)

2-9:

Brain herniation (brain herniation is a potentially deadly side effect of very high intracranial pressure that occurs when a part of the brain is squeezed across structures within the skull)
Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)
Brain stem haemorrhage (bleeding into structures of brain stem)
Disease progression
Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure)
Venoocclusive disease (small veins in the liver are obstructed)

10-19:

Agitation (state of anxiety or nervous excitement)
Hepatic necrosis (large portions of liver die off due to severe liver disease)
Overdose
Drug level below therapeutic

20-29:

Alanine aminotransferase increased
Aspartate aminotransferase increased
Cardiac failure
Delirium (wild excitement)
Respiratory failure (inadequate gas exchange by the respiratory system)
White blood cell count decreased

30-39:

Thrombosis (formation of a blood clot inside a blood vessel)
Thrombotic microangiopathy (a pathology that results in thrombosis in capillaries and arterioles, due to an endothelial injury)
Tremor (trembling or shaking movements in one or more parts of your body)
Ulcer
Ureaplasma test positive
Urine output decreased
Visual impairment
Weight decreased
White blood cell count decreased
Abdominal distension

40-49:

n/a

50-59:

Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)
Renal failure acute (rapid kidney dysfunction)
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)

60+:

Acute respiratory distress syndrome
Arthralgia (joint pain)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Pneumonia
Pneumonitis (inflammation of the walls of the alveoli in the lungs)
Pyelonephritis (inflammation of kidney caused by bacteria)
Acute generalised exanthematous pustulosis (acute febrile drug eruption)
Diarrhoea
Hepatitis cholestatic (flow of bile from the liver is slowed or blocked)
Methaemoglobinaemia (a disorder characterized by the presence of a higher than normal level of methemoglobin in blood)

What are the existing conditions these people have? *

Infection: 3 people, 11.54%
Primary Myelofibrosis (primary disorder of the bone marrow): 2 people, 7.69%
Oedema (fluid collection in tissue): 2 people, 7.69%
Multiple Myeloma (cancer of the plasma cells): 2 people, 7.69%
Hypovitaminosis (any of several diseases caused by deficiency of one or more vitamins): 2 people, 7.69%
Diarrhea: 2 people, 7.69%
Cytokine Release Syndrome (immediate complication occurring with the use of anti-t cell antibody infusions): 2 people, 7.69%
B-Cell Type Acute Leukaemia (cancer of the white blood cells): 2 people, 7.69%

* Approximation only. Some reports may have incomplete information.

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