Fentanyl and Vagifem drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Fentanyl (fentanyl citrate) and Vagifem (estradiol). Common drug interactions include pain in extremity among females.

The phase IV clinical study analyzes what interactions people have when they take Fentanyl and Vagifem. It is created by eHealthMe based on reports of 66 people who take the same drugs from the FDA, and is updated regularly.

What is Fentanyl?

Fentanyl has active ingredients of fentanyl citrate. It is often used in pain. eHealthMe is studying from 73,301 Fentanyl users. Check the latest studies of Fentanyl.

What is Vagifem?

Vagifem has active ingredients of estradiol. It is often used in vulvovaginal dryness. eHealthMe is studying from 6,263 Vagifem users. Check the latest studies of Vagifem.

On Jul, 13, 2026

66 people who take Fentanyl and Vagifem together, and have interactions are studied.

What are the common drug interactions of Fentanyl and Vagifem, by gender? *:

female:

Pain in extremity
Injury
Bone disorder
Cardiac failure congestive
Chondromalacia (anterior knee pain due to irritation of the cartilage on the under surface of the kneecap)
Deformity (disfigurement)
Dizziness
Dry mouth
Emotional distress
Epistaxis (bleed from the nose)

male:

n/a

What are the common drug interactions of Fentanyl and Vagifem, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Bipolar ii disorder (characterized by at least one episode of hypomania and at least one episode of major depression)
Drug ineffective
Exostosis (formation of new bone on the surface of a bone)
General physical health deterioration (weak health status)
Hip arthroplasty
Postoperative heterotopic calcification (process by which bone tissue forms outside of the skeleton after operative)
Suicidal ideation
Borderline personality disorder
Cervical spinal stenosis (narrowing of the spinal canal in the neck)
Depression

50-59:

Dizziness
Dry mouth
Emotional distress
Epistaxis (bleed from the nose)
Eye infection
Eye pain
Facial bones fracture (bone fracture of face)
Fall
Femur fracture
Glossitis (infection of tongue with soreness)

60+:

Vomiting
Chest pain
Abasia (inability to walk)
Arthralgia (joint pain)
Autoimmune disorder (a condition in which the immune system attacks the body's normal substances and tissue)
Blood pressure increased
Dehydration (dryness resulting from the removal of water)
Depressed level of consciousness
Diarrhoea
Gastritis (inflammation of stomach)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 13 people, 19.70%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 11 people, 16.67%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 9 people, 13.64%
Fibromyalgia (a long-term condition which causes pain all over the body): 9 people, 13.64%
Breast Cancer: 9 people, 13.64%
Osteoporosis (bones weak and more likely to break): 7 people, 10.61%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 6 people, 9.09%
High Blood Pressure: 6 people, 9.09%
Multiple Myeloma (cancer of the plasma cells): 5 people, 7.58%
High Blood Cholesterol: 5 people, 7.58%

* Approximation only. Some reports may have incomplete information.

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