Fentanyl and Zonegran drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Fentanyl (fentanyl citrate) and Zonegran (zonisamide). Common drug interactions include blood glucose increased among females and decreased appetite among males.

The phase IV clinical study analyzes what interactions people have when they take Fentanyl and Zonegran. It is created by eHealthMe based on reports of 35 people who take the same drugs from the FDA, and is updated regularly.

What is Fentanyl?

Fentanyl has active ingredients of fentanyl citrate. It is often used in pain. eHealthMe is studying from 73,301 Fentanyl users. Check the latest studies of Fentanyl.

What is Zonegran?

Zonegran has active ingredients of zonisamide. It is often used in epilepsy. eHealthMe is studying from 6,211 Zonegran users. Check the latest studies of Zonegran.

On Jul, 14, 2026

35 people who take Fentanyl and Zonegran together, and have interactions are studied.

Fentanyl and Zonegran drug interactions.

What are the common drug interactions of Fentanyl and Zonegran, by gender? *:

female:

Blood glucose increased
Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)
Breath sounds decreased
Cerebral haemorrhage (bleeding within the brain)
Coagulopathy (blood's ability to clot is impaired)
Confusional state
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Decreased immune responsiveness
Device occlusion
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)

male:

Decreased appetite
Dehydration (dryness resulting from the removal of water)
Cellulitis (infection under the skin)
Diabetes mellitus non-insulin-dependent
Hyperkalaemia (damage to or disease of the kidney)
Knee arthroplasty
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Pain in extremity
Wheezing (a high-pitched whistling sound made while you breath)
Diarrhoea

What are the common drug interactions of Fentanyl and Zonegran, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Neuroleptic malignant syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents)

20-29:

n/a

30-39:

Dry throat
Dysphagia (a condition in which swallowing is difficult or painful)
Oropharyngeal pain
Pharyngitis streptococcal (inflammation of the pharynx caused by infection from. streptococcus)
Pneumonia
Pulmonary artery thrombosis (blockage of the main artery of the lung)
Pyrexia (fever)
Syncope (loss of consciousness with an inability to maintain postural tone)

40-49:

Application site erythema (redness of the skin at application site)
Chest discomfort
Feeling cold
Hyperhidrosis (abnormally increased sweating)
Anxiety
Application site rash
Application site scar
Decreased immune responsiveness
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)

50-59:

Decubitus ulcer (a chronic ulcer of the skin caused by prolonged pressure on it)
Osteomyelitis (infection of bone)
Thermal burn (burn by heat)
Urinary tract infection
Abdominal discomfort
Asthenia (weakness)
Balance disorder
Cellulitis (infection under the skin)
Constipation
Device occlusion

60+:

Decreased appetite
Dehydration (dryness resulting from the removal of water)
Blood alkaline phosphatase increased
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Gingival disorder (gum disease)
Heparin-induced thrombocytopenia
Hypotension (abnormally low blood pressure)
Pneumothorax (the presence of air or gas in the cavity between the lungs and the chest wall, causing collapse of the lung)
Renal failure acute (rapid kidney dysfunction)

What are the existing conditions these people have? *

Sleep Disorder: 4 people, 11.43%
Depression: 4 people, 11.43%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 3 people, 8.57%
Back Pain: 3 people, 8.57%
Osteoporosis (bones weak and more likely to break): 3 people, 8.57%
Muscle Spasms (muscle contraction): 3 people, 8.57%
Migraine (headache): 3 people, 8.57%
High Blood Pressure: 3 people, 8.57%
High Blood Cholesterol: 3 people, 8.57%
Fibromyalgia (a long-term condition which causes pain all over the body): 2 people, 5.71%

* Approximation only. Some reports may have incomplete information.

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