Fentanyl and Zonisamide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Fentanyl (fentanyl citrate) and Zonisamide (zonisamide). Common drug interactions include dyspnoea among females and bradycardia among males.

The phase IV clinical study analyzes what interactions people have when they take Fentanyl and Zonisamide. It is created by eHealthMe based on reports of 57 people who take the same drugs from the FDA, and is updated regularly.

What is Fentanyl?

Fentanyl has active ingredients of fentanyl citrate. It is often used in pain. eHealthMe is studying from 73,301 Fentanyl users. Check the latest studies of Fentanyl.

What is Zonisamide?

Zonisamide has active ingredients of zonisamide. It is often used in epilepsy. eHealthMe is studying from 11,445 Zonisamide users. Check the latest studies of Zonisamide.

On Jul, 12, 2026

57 people who take Fentanyl and Zonisamide together, and have interactions are studied.

Fentanyl and Zonisamide drug interactions.

What are the common drug interactions of Fentanyl and Zonisamide, by gender? *:

female:

Dyspnoea (difficult or laboured respiration)
Epistaxis (bleed from the nose)
Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure)
Hyperammonaemic encephalopathy (excess of ammonia in the blood, disorder or disease of the brain)
Memory impairment
Myoclonus (a brief, involuntary twitching of a muscle or a group of muscles)
Nasal discharge discolouration (change in colour of nasal discharge)
Nausea (feeling of having an urge to vomit)
Nephrosclerosis (hardening of the kidney due to renovascular disease)
Neuropathy peripheral (surface nerve damage)

male:

Bradycardia (abnormally slow heart action)
Overdose
Rash
Visceral congestion (blocking of internal organs of the body)
Accidental death
Apathy
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Bradykinesia (decreased bodily movement. it is associated with basal ganglia diseases)
C-reactive protein increased
Cerebrospinal fluid leakage

What are the common drug interactions of Fentanyl and Zonisamide, by age (0-1 to 60+)? *:

0-1:

Bradycardia (abnormally slow heart action)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)

2-9:

n/a

10-19:

Delayed recovery from anaesthesia
Neuroleptic malignant syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents)
Abasia (inability to walk)
Anticonvulsant drug level increased
Drug ineffective
Grip strength decreased
Hyperammonaemic encephalopathy (excess of ammonia in the blood, disorder or disease of the brain)
Myoclonus (a brief, involuntary twitching of a muscle or a group of muscles)
Skin ulcer
Somnolence (a state of near-sleep, a strong desire for sleep)

20-29:

Bradycardia (abnormally slow heart action)
Cardiac arrest
Hypotension (abnormally low blood pressure)
Overdose
Pulseless electrical activity
Blood lactate dehydrogenase increased
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Depressed level of consciousness
Drug exposure during pregnancy
Dyskinesia (abnormality or impairment of voluntary movement)

30-39:

Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Drug toxicity
Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure)
Injection site burning
Multiple drug overdose intentional
Overdose
Respiratory arrest (cessation of normal respiration due to failure of the lungs to function effectively)
Aspartate aminotransferase increased
Coma (state of unconsciousness lasting more than six hours)
Completed suicide (act of taking one's own life)

40-49:

Drug abuse
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Death
Neoplasm malignant (cancer tumour)
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
Cardiac arrest
Poisoning
Psoriasis (immune-mediated disease that affects the skin)
Rectal ulcer haemorrhage (bleeding from rectum ulcer)
Respiratory arrest (cessation of normal respiration due to failure of the lungs to function effectively)

50-59:

Abdominal pain
Cardiac disorder
Chest pain
Rectal haemorrhage (bleeding from anus)
Chest discomfort
Genital pain (pain in genital)
Apathy
Bradykinesia (decreased bodily movement. it is associated with basal ganglia diseases)
Myotonia (a state of hyperexcitability in muscle fibres in which a voluntary contraction)
Nasal discharge discolouration (change in colour of nasal discharge)

60+:

Pulmonary oedema (fluid accumulation in the lungs)
Drug abuse
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
Transaminases increased
Visceral congestion (blocking of internal organs of the body)
Accidental death
Arthritis (form of joint disorder that involves inflammation of one or more joints)
C-reactive protein increased
Cerebrospinal fluid leakage
Confusional state

What are the existing conditions these people have? *

General Anaesthesia: 5 people, 8.77%
Muscle Function Loss: 4 people, 7.02%
Constipation: 4 people, 7.02%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 5.26%
Rectal Ulcer (ulcer of rectum): 3 people, 5.26%
Metastases To Lymph Nodes (cancer spreads to lymph node): 3 people, 5.26%
Metastases To Lung (cancer spreads to lung): 3 people, 5.26%
Metastases To Bone (cancer spreads to bone): 3 people, 5.26%
Breast Cancer Recurrent: 3 people, 5.26%
Abnormal Behavior: 3 people, 5.26%

* Approximation only. Some reports may have incomplete information.

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