Filspari and Tylenol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Filspari (sparsentan) and Tylenol (acetaminophen). Common drug interactions include renal impairment among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Filspari and Tylenol. It is created by eHealthMe based on reports of 32 people who take the same drugs from the FDA, and is updated regularly.

What is Filspari?

Filspari has active ingredients of sparsentan. eHealthMe is studying from 1,185 Filspari users. Check the latest studies of Filspari.

What is Tylenol?

Tylenol has active ingredients of acetaminophen. It is often used in pain. eHealthMe is studying from 222,309 Tylenol users. Check the latest studies of Tylenol.

On Jul, 25, 2026

32 people who take Filspari and Tylenol together, and have interactions are studied.

What are the common drug interactions of Filspari and Tylenol, by gender? *:

female:

Renal impairment (severely reduced kidney function)
Dizziness
Peripheral swelling
Fatigue (feeling of tiredness)
Somnolence (a state of near-sleep, a strong desire for sleep)
Cough
Abdominal pain lower
Glomerular filtration rate decreased
Pain in extremity
Protein s increased

male:

Fatigue (feeling of tiredness)
Abdominal discomfort
Back pain
Peripheral swelling
Abdominal distension
Anaemia (lack of blood)
Eye swelling
Face oedema (swelling of face)
Generalised oedema (swelling all over the body)
Myalgia (muscle pain)

What are the common drug interactions of Filspari and Tylenol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Dizziness
Fatigue (feeling of tiredness)
Glomerular filtration rate decreased
Pain in extremity
Peripheral swelling
Protein s increased
Renal impairment (severely reduced kidney function)
Somnolence (a state of near-sleep, a strong desire for sleep)
Abdominal pain upper
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)

20-29:

Blood pressure increased
Blood urine present
Chills (felling of cold)
Diarrhoea
Dizziness
Drug ineffective
Dry mouth
Dyspepsia (indigestion)
Fatigue (feeling of tiredness)
Hypoaesthesia (reduced sense of touch or sensation)

30-39:

Gastric infection (infection of stomach)
Renal impairment (severely reduced kidney function)
Influenza

40-49:

Fatigue (feeling of tiredness)
Dizziness
Abdominal discomfort
Abdominal distension
Abdominal pain upper
Alopecia (absence of hair from areas of the body)
Anaemia (lack of blood)
Arthralgia (joint pain)
Eye swelling
Face oedema (swelling of face)

50-59:

Back pain
Diarrhoea
Anxiety
Faeces discoloured
Flatulence (flatus expelled through the anus)
Urine abnormality
Abdominal discomfort
Hangover
Muscle spasms (muscle contraction)
Myalgia (muscle pain)

60+:

Nausea (feeling of having an urge to vomit)
Pruritus (severe itching of the skin)
Pain in extremity
Abdominal pain lower
Abdominal pain upper
Dizziness
Nasopharyngitis (inflammation of the nasopharynx)
Peripheral swelling
Sinusitis (inflammation of sinus)
Vomiting

What are the existing conditions these people have? *

Iga Nephropathy (kidney disease- condition prevents the kidneys from filtering waste): 31 people, 96.88%
Chronic Kidney Disease: 5 people, 15.62%
Haematuria (presence of blood in urine): 3 people, 9.38%

* Approximation only. Some reports may have incomplete information.

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