Fioricet w/ codeine and Premarin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Fioricet w/ codeine (acetaminophen; butalbital; caffeine; codeine phosphate) and Premarin (estrogens, conjugated). Common drug interactions include asthenia among females.

The phase IV clinical study analyzes what interactions people have when they take Fioricet w/ codeine and Premarin. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Fioricet w/ codeine?

Fioricet w/ codeine has active ingredients of acetaminophen; butalbital; caffeine; codeine phosphate. It is often used in migraine. eHealthMe is studying from 194 Fioricet w/ codeine users. Check the latest studies of Fioricet w/ codeine.

What is Premarin?

Premarin has active ingredients of estrogens, conjugated. It is often used in hormone replacement therapy. eHealthMe is studying from 99,630 Premarin users. Check the latest studies of Premarin.

On Jul, 12, 2026

11 people who take Fioricet w/ codeine and Premarin together, and have interactions are studied.

Fioricet w/ codeine and Premarin drug interactions.

What are the common drug interactions of Fioricet W/ Codeine and Premarin, by gender? *:

female:

Asthenia (weakness)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Breast cancer
Breast pain
Cervicobrachial syndrome (pain in neck and arm with changing location)
Chronic fatigue syndrome (disorder that causes extreme fatigue)
Depression
Dizziness
Dyspnoea (difficult or laboured respiration)

male:

n/a

What are the common drug interactions of Fioricet W/ Codeine and Premarin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Depression
Dizziness
Dyspnoea (difficult or laboured respiration)
Epigastric discomfort
Eye swelling
Fall
Fibromyalgia (a long-term condition which causes pain all over the body)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hot flush (sudden feelings of heat)
Hyperhidrosis (abnormally increased sweating)

50-59:

Asthenia (weakness)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Arthralgia (joint pain)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Breast cancer
Breast pain
Burning sensation
Cervicobrachial syndrome (pain in neck and arm with changing location)
Chronic fatigue syndrome (disorder that causes extreme fatigue)
Depression

60+:

n/a

What are the existing conditions these people have? *

Menopause (end of monthly cycles in women): 7 people, 63.64%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 7 people, 63.64%
Neuralgia (pain in one or more nerves): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

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