Fioricet w/ codeine and Zofran drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Fioricet w/ codeine (acetaminophen; butalbital; caffeine; codeine phosphate) and Zofran (ondansetron hydrochloride). Common drug interactions include accident among females and gastrointestinal haemorrhage among males.

The phase IV clinical study analyzes what interactions people have when they take Fioricet w/ codeine and Zofran. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Fioricet w/ codeine?

Fioricet w/ codeine has active ingredients of acetaminophen; butalbital; caffeine; codeine phosphate. It is often used in migraine. eHealthMe is studying from 194 Fioricet w/ codeine users. Check the latest studies of Fioricet w/ codeine.

What is Zofran?

Zofran has active ingredients of ondansetron hydrochloride. It is often used in nausea. eHealthMe is studying from 94,987 Zofran users. Check the latest studies of Zofran.

On Jul, 19, 2026

15 people who take Fioricet w/ codeine and Zofran together, and have interactions are studied.

Fioricet w/ codeine and Zofran drug interactions.

What are the common drug interactions of Fioricet W/ Codeine and Zofran, by gender? *:

female:

Accident
Chest pain
Foot fracture
Fatigue (feeling of tiredness)
Abdominal discomfort
Agitation (state of anxiety or nervous excitement)
Asthenia (weakness)
Constipation
Drooling (drop saliva uncontrollably from the mouth)
Glycosylated haemoglobin increased

male:

Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Anaemia (lack of blood)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Aortic valve incompetence
Arthralgia (joint pain)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Ascites (accumulation of fluid in the abdominal cavity)
Back pain

What are the common drug interactions of Fioricet W/ Codeine and Zofran, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Bipolar i disorder (mood disorder that is characterized by at least one manic or mixed episode)
Blood glucose decreased
Diabetes mellitus inadequate control
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Urinary tract infection
Accident
Chest pain
Foot fracture

40-49:

n/a

50-59:

Asthenia (weakness)
Constipation
Fatigue (feeling of tiredness)
Nodule (a growth of abnormal tissue)
Pain

60+:

Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Anaemia (lack of blood)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Aortic valve incompetence
Arthralgia (joint pain)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Ascites (accumulation of fluid in the abdominal cavity)
Back pain

What are the existing conditions these people have? *

Urinary Retention (the inability to completely or partially empty the bladder): 10 people, 66.67%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 10 people, 66.67%
Diabetes: 10 people, 66.67%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 10 people, 66.67%
Bipolar I Disorder (mood disorder that is characterized by at least one manic or mixed episode): 10 people, 66.67%
Quit Smoking: 10 people, 66.67%
Sinus Disorder (disease of sinus): 7 people, 46.67%
Multiple Myeloma (cancer of the plasma cells): 4 people, 26.67%
Diarrhea: 4 people, 26.67%
High Blood Pressure: 3 people, 20.00%

* Approximation only. Some reports may have incomplete information.

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