Fioricet and Emla drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Fioricet (acetaminophen; butalbital; caffeine) and Emla (lidocaine; prilocaine). Common drug interactions include fibromyalgia among females and abscess among males.

The phase IV clinical study analyzes what interactions people have when they take Fioricet and Emla. It is created by eHealthMe based on reports of 28 people who take the same drugs from the FDA, and is updated regularly.

What is Fioricet?

Fioricet has active ingredients of acetaminophen; butalbital; caffeine. It is often used in migraine. eHealthMe is studying from 12,423 Fioricet users. Check the latest studies of Fioricet.

What is Emla?

Emla has active ingredients of lidocaine; prilocaine. eHealthMe is studying from 5,276 Emla users. Check the latest studies of Emla.

On Aug, 01, 2026

28 people who take Fioricet and Emla together, and have interactions are studied.

What are the common drug interactions of Fioricet and Emla, by gender? *:

female:

Fibromyalgia (a long-term condition which causes pain all over the body)
Fluid retention (an abnormal accumulation of fluid in the blood)
Gait disturbance
Arthralgia (joint pain)
Fatigue (feeling of tiredness)
Pain
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Back pain
Chest discomfort
Intervertebral disc protrusion (spinal disc protrusion)

male:

Abscess (pus)
Abscess limb (limb infection)
Rectal abscess (pus in rectum)
Renal failure (kidney dysfunction)
Sepsis (a severe blood infection that can lead to organ failure and death)
Tooth abscess (pus formation in tooth)
Urinary tract infection
Wound infection
Genital abscess (build up of pus in genital)
Hospitalisation

What are the common drug interactions of Fioricet and Emla, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Disease progression
Lung neoplasm malignant (cancer tumour of lung)
Pulmonary embolism (blockage of the main artery of the lung)

30-39:

Abdominal pain upper
Aphasia (damage to the parts of the brain that control language)
Arthralgia (joint pain)
Blood creatinine increased
Blood glucose decreased
Blood urea increased
Chest discomfort
Clumsiness (a lack of coordination or elegance)
Constipation
Dyspareunia (painful sexual intercourse)

40-49:

Sensitivity of teeth
Sepsis (a severe blood infection that can lead to organ failure and death)
Tooth abscess (pus formation in tooth)
Urinary tract infection
Wound infection
Genital abscess (build up of pus in genital)
Hyperhidrosis (abnormally increased sweating)
Lymphadenitis (inflammation or enlargement of a lymph node)
Lymphangitis (inflammation of the lymph channel)
Cellulitis (infection under the skin)

50-59:

Back pain
Borderline personality disorder
Chronic kidney disease
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Diarrhoea
Dumping syndrome (a condition that can develop after surgery to remove all or part of your stomach or after surgery to bypass your stomach to help you lose weight)
Endometriosis (appearance of endometrial tissue outside the uterus and causing pelvic pain)
Fibromyalgia (a long-term condition which causes pain all over the body)
Gait disturbance

60+:

Hypoacusis (loss of hearing)
Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)

What are the existing conditions these people have? *

Nausea (feeling of having an urge to vomit): 14 people, 50.00%
Pain: 11 people, 39.29%
Stress And Anxiety: 10 people, 35.71%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 9 people, 32.14%
Constipation: 7 people, 25.00%
Nausea And Vomiting: 7 people, 25.00%
High Blood Pressure: 7 people, 25.00%
Abdominal Pain: 5 people, 17.86%
Seasonal Allergy (allergic condition due to certain season): 5 people, 17.86%
Pancreatic Carcinoma Metastatic (pancreatic cancer- metastatic): 5 people, 17.86%

* Approximation only. Some reports may have incomplete information.

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