Fioricet and Folate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Fioricet (acetaminophen; butalbital; caffeine) and Folate (folic acid). Common drug interactions include breast mass among females and back pain among males.

The phase IV clinical study analyzes what interactions people have when they take Fioricet and Folate. It is created by eHealthMe based on reports of 42 people who take the same drugs from the FDA, and is updated regularly.

What is Fioricet?

Fioricet has active ingredients of acetaminophen; butalbital; caffeine. It is often used in migraine. eHealthMe is studying from 12,423 Fioricet users. Check the latest studies of Fioricet.

What is Folate?

Folate has active ingredients of folic acid. It is often used in rheumatoid arthritis. eHealthMe is studying from 6,546 Folate users. Check the latest studies of Folate.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 21, 2026

42 people who take Fioricet and Folate together, and have interactions are studied.

What are the common drug interactions of Fioricet and Folate, by gender? *:

female:

Breast mass
Injection site pain
Middle ear effusion (fluid in middle ear)
Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)
Urinary tract infection
Weight decreased
Respiratory tract infection viral
Anal fissure
Erythema (redness of the skin)
Sinusitis (inflammation of sinus)

male:

Back pain
Blood pressure increased
Depression
Emotional distress
Haemorrhagic anaemia (anaemia due to excessive bleeding)
Hypersexuality
Obsessive-compulsive personality disorder (a mental health condition in which a person is preoccupied with rules, orderliness, and control)
Pathological gambling
Suicidal ideation
Epistaxis (bleed from the nose)

What are the common drug interactions of Fioricet and Folate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Breast mass
Injection site pain
Middle ear effusion (fluid in middle ear)
Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)
Respiratory tract infection viral
Urinary tract infection
Weight decreased
Anal fissure
Erythema (redness of the skin)
Influenza

50-59:

Epistaxis (bleed from the nose)
Fatigue (feeling of tiredness)
Neck pain
Weight increased
Abdominal pain
Blood sodium increased
Diarrhoea
Faeces discoloured
Pain
Blood pressure increased

60+:

Muscle rupture (tear in muscle)
Nausea (feeling of having an urge to vomit)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Abdominal pain upper
Gastric ulcer (stomach ulcer)
Gastrointestinal disorder (functional problems of gastrointestinal tract)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 13 people, 30.95%
Immunodeficiency Common Variable: 13 people, 30.95%
Pain: 4 people, 9.52%
Restless Leg Syndrome (a powerful urge to move your legs): 3 people, 7.14%
Lambert-Eaton Syndrome (this means your immune system mistakenly targets healthy cells and tissues in the body): 3 people, 7.14%
Insomnia (sleeplessness): 3 people, 7.14%
Headache (pain in head): 3 people, 7.14%

* Approximation only. Some reports may have incomplete information.

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