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Fioricet and Marijuana drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Fioricet (acetaminophen; butalbital; caffeine) and Marijuana (marijuana). Common drug interactions include unresponsive to stimuli among females and abdominal pain upper among males.

The phase IV clinical study analyzes what interactions people have when they take Fioricet and Marijuana. It is created by eHealthMe based on reports of 25 people who take the same drugs from the FDA, and is updated regularly.

What is Fioricet?

Fioricet has active ingredients of acetaminophen; butalbital; caffeine. It is often used in migraine. eHealthMe is studying from 12,423 Fioricet users. Check the latest studies of Fioricet.

What is Marijuana?

Marijuana has active ingredients of marijuana. It is often used in stress and anxiety. eHealthMe is studying from 7,397 Marijuana users. Check the latest studies of Marijuana.

On Jul, 06, 2026

25 people who take Fioricet and Marijuana together, and have interactions are studied.

Fioricet and Marijuana drug interactions.

What are the common drug interactions of Fioricet and Marijuana, by gender? *:

female:

  1. Unresponsive to stimuli
  2. Weight decreased
  3. Wound infection
  4. Abnormal behaviour
  5. Arrhythmia (irregular heartbeat)
  6. Blood pressure decreased
  7. Cellulitis (infection under the skin)
  8. Constipation
  9. Depressed mood
  10. Diarrhoea

male:

  1. Abdominal pain upper
  2. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  3. Weight decreased
  4. Abdominal distension
  5. Abdominal pain
  6. Alanine aminotransferase increased
  7. Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
  8. Aspartate aminotransferase increased
  9. Back pain
  10. Erectile dysfunction

What are the common drug interactions of Fioricet and Marijuana, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Hypoaesthesia (reduced sense of touch or sensation)
  2. Hypoventilation (too shallow or too slow breathing, which does not meet the needs of the body)
  3. Incision site pain
  4. Irritability
  5. Joint range of motion decreased (disease of joint movement)
  6. Loss of consciousness
  7. Mean cell volume decreased (less of the average red blood cell volume)
  8. Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
  9. Mobility decreased (ability to move is reduced)
  10. Monoplegia (a paralysis of a single limb)

30-39:

  1. Arrested labour
  2. Premature labour
  3. Agitation (state of anxiety or nervous excitement)
  4. Confusional state
  5. Suicide attempt

40-49:

  1. Abdominal pain upper
  2. Alanine aminotransferase increased
  3. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  4. Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
  5. Aspartate aminotransferase increased
  6. Back pain
  7. Emotional distress
  8. Erectile dysfunction
  9. Flat affect (absence of emotional response to a situation)
  10. Liver injury

50-59:

  1. Dyspnoea (difficult or laboured respiration)
  2. Nasal dryness (dry nose)
  3. Pancreatic disorder
  4. Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
  5. Sinusitis (inflammation of sinus)
  6. Abdominal distension
  7. Abdominal pain upper
  8. Agitation (state of anxiety or nervous excitement)
  9. Cellulitis (infection under the skin)
  10. Confusional state

60+:

  1. Drug dependence
  2. Hepatitis c
  3. Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)

What are the existing conditions these people have? *

  1. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 20.00%
  2. Depression: 3 people, 12.00%
  3. Vitamin B12 Deficiency: 2 people, 8.00%
  4. Hiv Infection: 2 people, 8.00%
  5. Asthma: 2 people, 8.00%
  6. Bipolar Disorder (mood disorder): 2 people, 8.00%
  7. Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 2 people, 8.00%
  8. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 8.00%
  9. Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 2 people, 8.00%
  10. Headache (pain in head): 2 people, 8.00%

* Approximation only. Some reports may have incomplete information.

Do you take Fioricet and Marijuana?

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- Predict drug outcomes for up to one year with AI
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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Fioricet and Marijuana:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Fioricet:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Marijuana:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Fioricet and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Marijuana and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; butalbital; caffeine and marijuana (the active ingredients of Fioricet and Marijuana, respectively), and Fioricet and Marijuana (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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