Fioricet and Naltrexone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Fioricet (acetaminophen; butalbital; caffeine) and Naltrexone (naltrexone). Common drug interactions include infusion related reaction among females and cognitive disorder among males.

The phase IV clinical study analyzes what interactions people have when they take Fioricet and Naltrexone. It is created by eHealthMe based on reports of 30 people who take the same drugs from the FDA, and is updated regularly.

What is Fioricet?

Fioricet has active ingredients of acetaminophen; butalbital; caffeine. It is often used in migraine. eHealthMe is studying from 12,423 Fioricet users. Check the latest studies of Fioricet.

What is Naltrexone?

Naltrexone has active ingredients of naltrexone. eHealthMe is studying from 4,835 Naltrexone users. Check the latest studies of Naltrexone.

On Aug, 05, 2026

30 people who take Fioricet and Naltrexone together, and have interactions are studied.

Fioricet and Naltrexone drug interactions.

What are the common drug interactions of Fioricet and Naltrexone, by gender? *:

female:

Infusion related reaction
Fall
Drug ineffective
Pyelonephritis (inflammation of kidney caused by bacteria)
Urinary tract infection
Anxiety
Balance disorder
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Drug hypersensitivity
Gait disturbance

male:

Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Tick-borne fever (fever due to tick bite infection)
Circadian rhythm sleep disorder (family of sleep disorders affecting, among other things, the timing of sleep)
Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Hypersomnia (excessive daytime sleepiness (eds))
Bacterial infection

What are the common drug interactions of Fioricet and Naltrexone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Bacterial infection

20-29:

n/a

30-39:

Abortion spontaneous (naturally occurring miscarriage)
Anxiety
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Diarrhoea
Drug ineffective
Fatigue (feeling of tiredness)
Hypersensitivity
Hypertension (high blood pressure)
Lymphadenopathy (disease or enlargement of lymph nodes)
Nasopharyngitis (inflammation of the nasopharynx)

40-49:

Adverse reaction
Muscle spasms (muscle contraction)

50-59:

Asthenia (weakness)
Balance disorder
Hypoaesthesia (reduced sense of touch or sensation)
Hypotension (abnormally low blood pressure)
Influenza like illness
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Muscular weakness (muscle weakness)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Pleurisy (inflammation of the pleurae, which causes pain when breathing)
Rhinorrhoea (watery mucus discharge from the nose)

60+:

n/a

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 10 people, 33.33%
Immunodeficiency Common Variable: 5 people, 16.67%
Drowsiness: 4 people, 13.33%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 6.67%
Irritable Bowel Syndrome: 2 people, 6.67%
Inflammatory Bowel Disease: 2 people, 6.67%
Headache (pain in head): 2 people, 6.67%
Bipolar Disorder (mood disorder): 2 people, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Fioricet and Naltrexone?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously