Fiorinal and Lanoxin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Fiorinal (aspirin; butalbital; caffeine) and Lanoxin (digoxin). Common drug interactions include dyspnoea paroxysmal nocturnal among females and depression among males.

The phase IV clinical study analyzes what interactions people have when they take Fiorinal and Lanoxin. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Fiorinal?

Fiorinal has active ingredients of aspirin; butalbital; caffeine. It is often used in migraine. eHealthMe is studying from 2,714 Fiorinal users. Check the latest studies of Fiorinal.

What is Lanoxin?

Lanoxin has active ingredients of digoxin. It is often used in atrial fibrillation/flutter. eHealthMe is studying from 21,852 Lanoxin users. Check the latest studies of Lanoxin.

On Jul, 09, 2026

13 people who take Fiorinal and Lanoxin together, and have interactions are studied.

What are the common drug interactions of Fiorinal and Lanoxin, by gender? *:

female:

Dyspnoea paroxysmal nocturnal (respiratory distress that awakens patients from sleep)
Epistaxis (bleed from the nose)
Facial pain
Fatigue (feeling of tiredness)
Fibromyalgia (a long-term condition which causes pain all over the body)
Flatulence (flatus expelled through the anus)
Gastritis (inflammation of stomach)
Glucose tolerance impaired (blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis)
Hepatic steatosis (fatty liver disease)
Histrionic personality disorder (long-standing pattern of attention seeking behaviour and extreme emotionality)

male:

Depression
Anaemia (lack of blood)
Constipation
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Coronary artery stenosis (narrowing of coronary artery)
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Dyspnoea (difficult or laboured respiration)
Emotional distress
Erectile dysfunction
Fear

What are the common drug interactions of Fiorinal and Lanoxin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Drug hypersensitivity

40-49:

Anaemia (lack of blood)
Angina pectoris (chest pain due to ischemia of the heart muscle)
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Arthropathy
Back disorder
Cardiomegaly (increased size of heart than normal)
Cardiovascular disorder (heart diseases)
Chest pain
Constipation
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)

50-59:

Limb discomfort (discomfort in leg)
Malaise (a feeling of general discomfort or uneasiness)
Menopausal symptoms
Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)
Muscle spasms (muscle contraction)
Musculoskeletal chest pain (pain in chest muscle or nerve or bones)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Myalgia (muscle pain)
Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)
Myofascial pain syndrome (a painful condition that affects the muscles and the sheath of the tissue)

60+:

Abdominal pain
Acute respiratory failure
Flatulence (flatus expelled through the anus)
Hypovolaemia (a decreased volume of circulating blood in the body)
Leukocytosis (increased white blood cells)
Lymphadenopathy mediastinal (an enlargement of the lymph nodes in the part of the chest that separates the lungs)
Metabolic encephalopathy (disorder or disease of the brain due to the body's disability to use energy)
Muscle twitching
Oedema peripheral (superficial swelling)
Pleural effusion (water on the lungs)

What are the existing conditions these people have? *

Wolff-Parkinson-White Syndrome (a heart condition in which there is an abnormal extra electrical pathway of the heart): 2 people, 15.38%
Stable Angina (a constant chest pain): 2 people, 15.38%
Back Pain: 2 people, 15.38%
Parkinson's Disease: 2 people, 15.38%
Depression: 2 people, 15.38%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 2 people, 15.38%
Oral Herpes (viral infection of mouth): 2 people, 15.38%
Oedema Peripheral (superficial swelling): 2 people, 15.38%
Neuralgia (pain in one or more nerves): 2 people, 15.38%
Gout (uric acid crystals building up in the body): 2 people, 15.38%

* Approximation only. Some reports may have incomplete information.

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