Fiorinal and Sumatriptan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Fiorinal (aspirin; butalbital; caffeine) and Sumatriptan (sumatriptan succinate). Common drug interactions include osteoarthritis among females and asthenia among males.

The phase IV clinical study analyzes what interactions people have when they take Fiorinal and Sumatriptan. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Fiorinal?

Fiorinal has active ingredients of aspirin; butalbital; caffeine. It is often used in migraine. eHealthMe is studying from 2,714 Fiorinal users. Check the latest studies of Fiorinal.

What is Sumatriptan?

Sumatriptan has active ingredients of sumatriptan succinate. It is often used in migraine. eHealthMe is studying from 18,159 Sumatriptan users. Check the latest studies of Sumatriptan.

On Jul, 21, 2026

24 people who take Fiorinal and Sumatriptan together, and have interactions are studied.

Fiorinal and Sumatriptan drug interactions.

What are the common drug interactions of Fiorinal and Sumatriptan, by gender? *:

female:

Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Fungal infection
Gait disturbance
Gastritis (inflammation of stomach)
Generalised oedema (swelling all over the body)
Asthenia (weakness)
Dry mouth
Fall
Femur fracture
Osteoporosis (bones weak and more likely to break)

male:

Asthenia (weakness)
Confusional state
Drug ineffective
Nausea (feeling of having an urge to vomit)
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Peripheral coldness
Pyrexia (fever)
White blood cell count decreased

What are the common drug interactions of Fiorinal and Sumatriptan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Asthenia (weakness)
Chest discomfort
Dizziness
Hypokinesia (decreased bodily movement)
Vomiting

30-39:

Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)
Depressed level of consciousness
Paranasal sinus discomfort
Paranasal sinus hypersecretion

40-49:

Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Pulmonary embolism (blockage of the main artery of the lung)
Sweating increased (excess sweating)

50-59:

Haemorrhagic anaemia (anaemia due to excessive bleeding)
Hypoaesthesia (reduced sense of touch or sensation)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Metastases to central nervous system (cancer spreads to central nervous system)
Pain
Pneumonia
Pneumonia bacterial (pneumonia associated with bacterial infection)
Pulmonary alveolar haemorrhage (acute bleeding)
Pulmonary haemorrhage (acute bleeding from the lung)
Pyrexia (fever)

60+:

Asthenia (weakness)
Dry mouth
Dizziness
Femur fracture
Foot fracture
Fracture nonunion (permanent failure of healing following a broken bone)
Low turnover osteopathy (slow removal of old bone and its replacement by new bone)
Lung neoplasm (tumour of lung)
Muscle atrophy (a decrease in the mass of the muscle)
Osteopenia (a condition where bone mineral density is lower than normal)

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 5 people, 20.83%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 12.50%
Stress And Anxiety: 2 people, 8.33%
Osteopenia (a condition where bone mineral density is lower than normal): 2 people, 8.33%
Nausea (feeling of having an urge to vomit): 2 people, 8.33%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 8.33%
Micturition Urgency (urgency to pass the urine): 2 people, 8.33%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 8.33%
High Blood Pressure: 2 people, 8.33%
Headache (pain in head): 2 people, 8.33%

* Approximation only. Some reports may have incomplete information.

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