Fiorinal and Topiramate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Fiorinal (aspirin; butalbital; caffeine) and Topiramate (topiramate). Common drug interactions include tooth infection among females.

The phase IV clinical study analyzes what interactions people have when they take Fiorinal and Topiramate. It is created by eHealthMe based on reports of 50 people who take the same drugs from the FDA, and is updated regularly.

What is Fiorinal?

Fiorinal has active ingredients of aspirin; butalbital; caffeine. It is often used in migraine. eHealthMe is studying from 2,714 Fiorinal users. Check the latest studies of Fiorinal.

What is Topiramate?

Topiramate has active ingredients of topiramate. It is often used in migraine. eHealthMe is studying from 49,809 Topiramate users. Check the latest studies of Topiramate.

On Jul, 31, 2026

50 people who take Fiorinal and Topiramate together, and have interactions are studied.

Fiorinal and Topiramate drug interactions.

What are the common drug interactions of Fiorinal and Topiramate, by gender? *:

female:

Tooth infection
Back pain
Injury
Nausea (feeling of having an urge to vomit)
Neck pain
Seasonal allergy (allergic condition due to certain season)
Anxiety
Cellulitis (infection under the skin)
Hypertension (high blood pressure)
Multiple fractures

male:

n/a

What are the common drug interactions of Fiorinal and Topiramate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Blood oestrogen decreased
Decreased appetite
Dizziness
Fatigue (feeling of tiredness)
Fibromyalgia (a long-term condition which causes pain all over the body)
Head discomfort
Hypothalamo-pituitary disorder (loss of function in an endocrine gland due to failure of the pituitary gland to secrete hormones which stimulate that gland's function)
Nausea (feeling of having an urge to vomit)

30-39:

Hypophosphataemia (electrolyte disturbance in which there is an abnormally low level of phosphate in the blood)
Alopecia (absence of hair from areas of the body)
Anxiety
Blood potassium decreased
Cardiogenic shock (inadequate circulation of blood)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Dysarthria (speech disorder)
Emotional distress
General physical health deterioration (weak health status)
Heart rate irregular

40-49:

Bronchitis (inflammation of the mucous membrane in the bronchial tubes)

50-59:

Injection site urticaria (rash of round, red welts on the skin at injection site)
Insomnia (sleeplessness)
Joint stiffness
Malaise (a feeling of general discomfort or uneasiness)
Muscle spasms (muscle contraction)
Muscular weakness (muscle weakness)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Myofascial pain syndrome (a painful condition that affects the muscles and the sheath of the tissue)
Nausea (feeling of having an urge to vomit)
Neck pain

60+:

Back pain
Fall
Diarrhoea
Drug eruption (adverse drug reaction of the skin)
Eye disorder
Fatigue (feeling of tiredness)
Gastrointestinal obstruction
Nausea (feeling of having an urge to vomit)
Oropharyngeal pain
Osteoporosis (bones weak and more likely to break)

What are the existing conditions these people have? *

Myasthenia Gravis (a chronic condition that causes muscles to tire and weaken easily): 10 people, 20.00%
Lambert-Eaton Syndrome (this means your immune system mistakenly targets healthy cells and tissues in the body): 10 people, 20.00%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 6 people, 12.00%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 5 people, 10.00%
Headache (pain in head): 5 people, 10.00%
Sleep Disorder: 4 people, 8.00%
Pain: 4 people, 8.00%
Immunodeficiency Common Variable: 4 people, 8.00%
High Blood Pressure: 4 people, 8.00%
Primary Immunodeficiency Syndrome: 3 people, 6.00%

* Approximation only. Some reports may have incomplete information.

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