Firazyr and Effexor drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Firazyr (icatibant acetate) and Effexor (venlafaxine hydrochloride). Common drug interactions include hereditary angioedema among females and hereditary angioedema among males.

The phase IV clinical study analyzes what interactions people have when they take Firazyr and Effexor. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Firazyr?

Firazyr has active ingredients of icatibant acetate. eHealthMe is studying from 5,650 Firazyr users. Check the latest studies of Firazyr.

What is Effexor?

Effexor has active ingredients of venlafaxine hydrochloride. It is often used in depression. eHealthMe is studying from 99,493 Effexor users. Check the latest studies of Effexor.



On Jul, 27, 2026

18 people who take Firazyr and Effexor together, and have interactions are studied.

Firazyr and Effexor drug interactions.

What are the common drug interactions of Firazyr and Effexor, by gender? *:

female:

  1. Hereditary angioedema (recurrent episodes of severe swelling)
  2. Drug ineffective
  3. Device related infection
  4. Pneumonia
  5. Sepsis (a severe blood infection that can lead to organ failure and death)
  6. Renal embolism (an obstruction in a kidney)
  7. Renal impairment (severely reduced kidney function)
  8. Deafness
  9. Exfoliative rash (scaly red generalized skin rash)
  10. Lupus nephritis (a chronic inflammatory autoimmune disorder that may affect kidney tissue)

male:

  1. Hereditary angioedema (recurrent episodes of severe swelling)
  2. Chest pain
  3. Lupus nephritis (a chronic inflammatory autoimmune disorder that may affect kidney tissue)
  4. Pulmonary embolism (blockage of the main artery of the lung)
  5. Renal impairment (severely reduced kidney function)
  6. Sepsis (a severe blood infection that can lead to organ failure and death)
  7. Staphylococcal infection (an infection with staphylococcus bacteria)
  8. Device related infection
  9. Drug ineffective
  10. Dysphonia (speech disorder attributable to a disorder of phonation)

What are the common drug interactions of Firazyr and Effexor, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Chest pain
  2. Dyspnoea (difficult or laboured respiration)
  3. Heart rate increased
  4. Hereditary angioedema (recurrent episodes of severe swelling)
  5. Pulmonary embolism (blockage of the main artery of the lung)

30-39:

  1. Device related infection
  2. Hereditary angioedema (recurrent episodes of severe swelling)
  3. Sepsis (a severe blood infection that can lead to organ failure and death)
  4. Renal embolism (an obstruction in a kidney)
  5. Renal impairment (severely reduced kidney function)
  6. Lupus nephritis (a chronic inflammatory autoimmune disorder that may affect kidney tissue)
  7. Nephrolithiasis (calculi in the kidneys)
  8. Pharyngitis streptococcal (inflammation of the pharynx caused by infection from. streptococcus)
  9. Therapeutic response unexpected
  10. Transaminases increased

40-49:

n/a

50-59:

  1. Device related infection
  2. Exfoliative rash (scaly red generalized skin rash)
  3. Urinary tract infection
  4. Flushing (the warm, red condition of human skin)
  5. General physical health deterioration (weak health status)
  6. Hereditary angioedema (recurrent episodes of severe swelling)
  7. Lupus nephritis (a chronic inflammatory autoimmune disorder that may affect kidney tissue)
  8. Rash erythematous (redness of the skin)
  9. Renal impairment (severely reduced kidney function)
  10. Sepsis (a severe blood infection that can lead to organ failure and death)

60+:

n/a

What are the existing conditions these people have? *

  1. Hereditary Angioedema (recurrent episodes of severe swelling): 14 people, 77.78%
  2. Pain: 6 people, 33.33%
  3. Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 4 people, 22.22%
  4. Immune System Disorder: 4 people, 22.22%
  5. Essential Hypertension (primary hypertension): 4 people, 22.22%
  6. Dyspnea (difficult or laboured breathing): 4 people, 22.22%
  7. Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 2 people, 11.11%
  8. Stress And Anxiety: 1 person, 5.56%
  9. Pulmonary Embolism (blockage of the main artery of the lung): 1 person, 5.56%
  10. Psoriasis (immune-mediated disease that affects the skin): 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Firazyr and Effexor:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Firazyr:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Effexor:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Firazyr and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Effexor and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on icatibant acetate and venlafaxine hydrochloride (the active ingredients of Firazyr and Effexor, respectively), and Firazyr and Effexor (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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