Flagyl and Glycopyrrolate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Flagyl (metronidazole) and Glycopyrrolate (glycopyrrolate). Common drug interactions include depression among females and subarachnoid haemorrhage among males.

The phase IV clinical study analyzes what interactions people have when they take Flagyl and Glycopyrrolate. It is created by eHealthMe based on reports of 26 people who take the same drugs from the FDA, and is updated regularly.

What is Flagyl?

Flagyl has active ingredients of metronidazole. It is often used in vaginitis bacterial. eHealthMe is studying from 25,897 Flagyl users. Check the latest studies of Flagyl.

What is Glycopyrrolate?

Glycopyrrolate has active ingredients of glycopyrrolate. It is often used in hyperhidrosis. eHealthMe is studying from 5,599 Glycopyrrolate users. Check the latest studies of Glycopyrrolate.



On Jul, 19, 2026

26 people who take Flagyl and Glycopyrrolate together, and have interactions are studied.

Flagyl and Glycopyrrolate drug interactions.

What are the common drug interactions of Flagyl and Glycopyrrolate, by gender? *:

female:

  1. Depression
  2. Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
  3. Dyslipidaemia (abnormal amount of lipids)
  4. Dyspepsia (indigestion)
  5. Dyspnoea (difficult or laboured respiration)
  6. Ejection fraction decreased (systolic heart failure)
  7. Electrocardiogram st segment elevation
  8. Electrocardiogram st-t change
  9. Enteritis (inflammation of the small intestine)
  10. Enterocolitis infectious

male:

  1. Subarachnoid haemorrhage (blood leaks into the space between two membranes that surround the brain)
  2. Sepsis (a severe blood infection that can lead to organ failure and death)
  3. Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
  4. Hypotension (abnormally low blood pressure)
  5. Nausea (feeling of having an urge to vomit)
  6. Neuroleptic malignant syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents)
  7. Pneumonia
  8. Renal failure acute (rapid kidney dysfunction)
  9. Renal tubular necrosis (death of kidney tubules)
  10. Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)

What are the common drug interactions of Flagyl and Glycopyrrolate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

  1. Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
  2. Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
  3. Urticaria (rash of round, red welts on the skin that itch intensely)
  4. Colitis ulcerative (inflammation of colon with ulcer)

20-29:

  1. Abdominal pain
  2. Nausea (feeling of having an urge to vomit)
  3. Vomiting
  4. Biliary colic
  5. Cholecystitis (infection of gallbladder)
  6. Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
  7. Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)
  8. Vaginal haemorrhage (vaginal bleeding)
  9. Pneumonia

30-39:

  1. Cholecystitis chronic (long lasting infection of gallbladder)
  2. Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
  3. Pulmonary embolism (blockage of the main artery of the lung)

40-49:

n/a

50-59:

  1. Muscular weakness (muscle weakness)
  2. Nausea (feeling of having an urge to vomit)
  3. Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
  4. Pain in extremity
  5. Pancreatitis (inflammation of pancreas)
  6. Perirectal abscess
  7. Pneumonia
  8. Rectal abscess (pus in rectum)
  9. Renal failure (kidney dysfunction)
  10. Renal tubular necrosis (death of kidney tubules)

60+:

  1. Septic shock (shock due to blood infection)
  2. Sepsis (a severe blood infection that can lead to organ failure and death)
  3. Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
  4. Colitis ischaemic (due to infection of intestine impaired blood supply to colon)
  5. Constipation
  6. Cystitis (inflammation of the wall of the bladder)
  7. Dehydration (dryness resulting from the removal of water)
  8. Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs)
  9. Gastric ulcer (stomach ulcer)
  10. Gastroenteritis (inflammation of stomach and intestine)

What are the existing conditions these people have? *

  1. Pain: 6 people, 23.08%
  2. Nausea (feeling of having an urge to vomit): 6 people, 23.08%
  3. Fever: 5 people, 19.23%
  4. Insomnia (sleeplessness): 5 people, 19.23%
  5. The Flu (the flu is caused by an influenza virus): 4 people, 15.38%
  6. Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 4 people, 15.38%
  7. Dyspnea (difficult or laboured breathing): 4 people, 15.38%
  8. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 15.38%
  9. Hypotension (abnormally low blood pressure): 3 people, 11.54%
  10. Chest Pain: 3 people, 11.54%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Flagyl and Glycopyrrolate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Flagyl:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Glycopyrrolate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Flagyl and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Glycopyrrolate and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on metronidazole and glycopyrrolate (the active ingredients of Flagyl and Glycopyrrolate, respectively), and Flagyl and Glycopyrrolate (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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