Flagyl and Imodium a-d drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Flagyl (metronidazole) and Imodium a-d (loperamide hydrochloride). Common drug interactions include neuropathy peripheral among females and abdominal distension among males.

The phase IV clinical study analyzes what interactions people have when they take Flagyl and Imodium a-d. It is created by eHealthMe based on reports of 47 people who take the same drugs from the FDA, and is updated regularly.

What is Flagyl?

Flagyl has active ingredients of metronidazole. It is often used in vaginitis bacterial. eHealthMe is studying from 25,897 Flagyl users. Check the latest studies of Flagyl.

What is Imodium a-d?

Imodium a-d has active ingredients of loperamide hydrochloride. It is often used in diarrhea. eHealthMe is studying from 8,944 Imodium a-d users. Check the latest studies of Imodium a-d.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

47 people who take Flagyl and Imodium a-d together, and have interactions are studied.

Flagyl and Imodium a-d drug interactions.

What are the common drug interactions of Flagyl and Imodium A-D, by gender? *:

female:

Neuropathy peripheral (surface nerve damage)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Drug hypersensitivity
Fall
Infection
Rotavirus infection
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Thrombosis (formation of a blood clot inside a blood vessel)

male:

Abdominal distension
Hyperhidrosis (abnormally increased sweating)
Pneumonia
Weight decreased
Weight increased
Abdominal discomfort
Abdominal pain upper
Anxiety
Arthralgia (joint pain)
Atelectasis (partial or complete collapse of the lung)

What are the common drug interactions of Flagyl and Imodium A-D, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Abdominal distension
Abdominal pain
Flatulence (flatus expelled through the anus)
Hyperhidrosis (abnormally increased sweating)
Weight decreased
Weight increased
Dehydration (dryness resulting from the removal of water)
Hyperphagia (an abnormal appetite for food)

10-19:

Abdominal pain
Gastroenteritis (inflammation of stomach and intestine)

20-29:

Proctalgia (pain in the rectum)

30-39:

Confusional state

40-49:

Arthralgia (joint pain)
Asthenia (weakness)
Atelectasis (partial or complete collapse of the lung)
Blood magnesium decreased
Blood sodium decreased
Bone disorder
Bone marrow disorder
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Candidiasis (candidiasis or thrush is a fungal infection)

50-59:

Drug ineffective
Pyrexia (fever)
Urticaria (rash of round, red welts on the skin that itch intensely)

60+:

Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Renal injury (kidney injury)
Neuropathy peripheral (surface nerve damage)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Anaemia (lack of blood)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Drug hypersensitivity
Fall
Infection
Pneumonia

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 11 people, 23.40%
Nausea (feeling of having an urge to vomit): 10 people, 21.28%
Pain: 9 people, 19.15%
Nausea And Vomiting: 7 people, 14.89%
Short-Bowel Syndrome (a condition in which the body cannot absorb enough fluids and nutrients because part of the small intestine is missing): 5 people, 10.64%
Myelodysplastic Syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged): 5 people, 10.64%
Stress And Anxiety: 4 people, 8.51%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 4 people, 8.51%
Constipation: 4 people, 8.51%
Depression: 4 people, 8.51%

* Approximation only. Some reports may have incomplete information.

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