Flagyl and Zinacef drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Flagyl (metronidazole) and Zinacef (cefuroxime sodium). Common drug interactions include tinnitus among females and renal failure acute among males.

The phase IV clinical study analyzes what interactions people have when they take Flagyl and Zinacef. It is created by eHealthMe based on reports of 69 people who take the same drugs from the FDA, and is updated regularly.

What is Flagyl?

Flagyl has active ingredients of metronidazole. It is often used in vaginitis bacterial. eHealthMe is studying from 25,897 Flagyl users. Check the latest studies of Flagyl.

What is Zinacef?

Zinacef has active ingredients of cefuroxime sodium. eHealthMe is studying from 1,802 Zinacef users. Check the latest studies of Zinacef.

On Jul, 10, 2026

69 people who take Flagyl and Zinacef together, and have interactions are studied.

What are the common drug interactions of Flagyl and Zinacef, by gender? *:

female:

Tinnitus (a ringing in the ears)
Hypoacusis (loss of hearing)
Ear congestion
Ear discomfort
Dizziness
Pulmonary embolism (blockage of the main artery of the lung)
Death
Adrenal haemorrhage (bleeding into the adrenal gland)
Anaphylactic reaction (serious allergic reaction)
Heparin-induced thrombocytopenia

male:

Renal failure acute (rapid kidney dysfunction)
Multi-organ failure (multisystem organ failure)
Gastritis haemorrhagic (inflammation of stomach with bleeding)
Hyperkalaemia (damage to or disease of the kidney)
Malaise (a feeling of general discomfort or uneasiness)
Myopathy (a muscular disease in which the muscle fibres do not function)
Pseudomembranous colitis (antibiotic-associated diarrhoea (aad), is an infection of the colon)
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Death
Dehydration (dryness resulting from the removal of water)

What are the common drug interactions of Flagyl and Zinacef, by age (0-1 to 60+)? *:

0-1:

Cough

2-9:

n/a

10-19:

n/a

20-29:

Anxiety
Disturbance in attention
Headache (pain in head)
Memory impairment
Restlessness (not able to rest)
Tinnitus (a ringing in the ears)
Hypoacusis (loss of hearing)
Ear congestion
Insomnia (sleeplessness)
Ear discomfort

30-39:

Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Depressed level of consciousness
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Sensory disturbance (sense disturbance)
Stupor (lack of critical cognitive function and level of consciousness)
Taste loss

40-49:

Blood bilirubin increased
Hypersensitivity
Hypotension (abnormally low blood pressure)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Bile duct obstruction (blockage in the tubes that carry bile from the liver to the gallbladder)
Rash generalised (rash on most of body parts)
Alanine aminotransferase increased
Aspartate aminotransferase increased
Bilirubin conjugated increased
Blood lactate dehydrogenase increased

50-59:

Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Fungus serology test positive
Gastritis haemorrhagic (inflammation of stomach with bleeding)
Hyperkalaemia (damage to or disease of the kidney)
Myopathy (a muscular disease in which the muscle fibres do not function)
Pseudomembranous colitis (antibiotic-associated diarrhoea (aad), is an infection of the colon)
Adrenal haemorrhage (bleeding into the adrenal gland)
Blood pressure decreased
Dehydration (dryness resulting from the removal of water)
Dysphagia (a condition in which swallowing is difficult or painful)

60+:

Multi-organ failure (multisystem organ failure)
Thrombocytopenia (decrease of platelets in blood)
Activated partial thromboplastin time prolonged
Acute abdomen
Acute respiratory distress syndrome
Blood fibrinogen decreased
Chills (felling of cold)
Face oedema (swelling of face)
Haematocrit decreased
Haemoglobin decreased

What are the existing conditions these people have? *

Pain: 7 people, 10.14%
High Blood Cholesterol: 7 people, 10.14%
Metabolic Acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body): 6 people, 8.70%
Fever: 6 people, 8.70%
Clostridium Difficile Colitis (inflammation of colon by clostridium difficile bacteria infection): 6 people, 8.70%
Streptococcal Infection: 5 people, 7.25%
Sepsis (a severe blood infection that can lead to organ failure and death): 5 people, 7.25%
Pneumonia: 5 people, 7.25%
Depression: 5 people, 7.25%
Pancreatic Carcinoma Metastatic (pancreatic cancer- metastatic): 4 people, 5.80%

* Approximation only. Some reports may have incomplete information.

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