Flolan and Ranitidine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Flolan (epoprostenol sodium) and Ranitidine (ranitidine). Common drug interactions include hypovolaemia among females and pain in jaw among males.

The phase IV clinical study analyzes what interactions people have when they take Flolan and Ranitidine. It is created by eHealthMe based on reports of 27 people who take the same drugs from the FDA, and is updated regularly.

What is Flolan?

Flolan has active ingredients of epoprostenol sodium. eHealthMe is studying from 10,067 Flolan users. Check the latest studies of Flolan.

What is Ranitidine?

Ranitidine has active ingredients of ranitidine. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 234,475 Ranitidine users. Check the latest studies of Ranitidine.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 22, 2026

27 people who take Flolan and Ranitidine together, and have interactions are studied.

Flolan and Ranitidine drug interactions.

What are the common drug interactions of Flolan and Ranitidine, by gender? *:

female:

Hypovolaemia (a decreased volume of circulating blood in the body)
Intraductal papillary mucinous neoplasm (tumour (neoplasm) that grows within the pancreatic ducts)
Migraine (headache)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Overdose
Pancreatic cyst
Peripheral swelling
Presyncope
Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)
Headache (pain in head)

male:

Pain in jaw
Flushing (the warm, red condition of human skin)
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Fatigue (feeling of tiredness)
Heart rate decreased
Infusion related reaction
Mean arterial pressure decreased (less than an average blood pressure in an individual)
Myelodysplastic syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged)
Optic ischaemic neuropathy (optic nerve damage due to lack of blood supply)
Syncope (loss of consciousness with an inability to maintain postural tone)

What are the common drug interactions of Flolan and Ranitidine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Optic ischaemic neuropathy (optic nerve damage due to lack of blood supply)
Visual acuity reduced (reduced clearness of vision)

20-29:

n/a

30-39:

Alanine aminotransferase increased
Anaemia (lack of blood)
Catheter site haemorrhage (bleeding at catheter site)
Platelet count decreased
Right ventricular failure (right half of the heart fails to work)
Aspartate aminotransferase increased
Haematoma (collection of blood outside the blood vessels)
Haemoglobin decreased
Headache (pain in head)
Nausea (feeling of having an urge to vomit)

40-49:

Myalgia (muscle pain)
Nausea (feeling of having an urge to vomit)
Oedema peripheral (superficial swelling)
Pain in jaw
Right ventricular failure (right half of the heart fails to work)
Vomiting
Weight increased
Death
Device related infection
Fatigue (feeling of tiredness)

50-59:

Fatigue (feeling of tiredness)
Headache (pain in head)
Weight decreased
Device related infection
Upper respiratory tract infection
Allergic sinusitis
Catheter site discharge
Catheter site erythema (redness of skin at catheter site)
Catheter site infection (infection at the site of insertion)
Cellulitis (infection under the skin)

60+:

Nausea (feeling of having an urge to vomit)
Dyspnoea (difficult or laboured respiration)
Aspartate aminotransferase increased
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
Chills (felling of cold)
Death
Diarrhoea
Dizziness
Fatigue (feeling of tiredness)

What are the existing conditions these people have? *

Pulmonary Hypertension (increase in blood pressure in the lung artery): 15 people, 55.56%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 15 people, 55.56%
Skin Ulcer: 2 people, 7.41%
Pulmonary Hypertension Primary (increase in blood pressure in the lung artery with no cause): 2 people, 7.41%

* Approximation only. Some reports may have incomplete information.

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