Flomax and Sonata drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Flomax (tamsulosin hydrochloride) and Sonata (zaleplon). Common drug interactions include musculoskeletal pain among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Flomax and Sonata. It is created by eHealthMe based on reports of 50 people who take the same drugs from the FDA, and is updated regularly.

What is Flomax?

Flomax has active ingredients of tamsulosin hydrochloride. It is often used in enlarged prostate. eHealthMe is studying from 52,865 Flomax users. Check the latest studies of Flomax.

What is Sonata?

Sonata has active ingredients of zaleplon. It is often used in insomnia. eHealthMe is studying from 3,330 Sonata users. Check the latest studies of Sonata.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 26, 2026

50 people who take Flomax and Sonata together, and have interactions are studied.

What are the common drug interactions of Flomax and Sonata, by gender? *:

female:

Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Nausea (feeling of having an urge to vomit)
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure acute (rapid kidney dysfunction)
Respiratory disorder (respiratory disease)
Rhinitis allergic (inflammation of the nasal airways due to allergy)
Temporomandibular joint syndrome (pain at the temporomandibular joint due to various causes of increased muscle tension and spasm. it is believed that syndrome is a physical manifestation of psychological stress)
Type 2 diabetes mellitus
Arthralgia (joint pain)
Blood cholesterol increased

male:

Anxiety
Depression
Nausea (feeling of having an urge to vomit)
Pain
Bipolar disorder (mood disorder)
Chest pain
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Drug ineffective
Dysarthria (speech disorder)
Hypertension (high blood pressure)

What are the common drug interactions of Flomax and Sonata, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Anaemia (lack of blood)
Renal cell carcinoma stage unspecified (kidney cancer in unknown stage)

10-19:

n/a

20-29:

n/a

30-39:

Anger
Anxiety
Bipolar disorder (mood disorder)
Blood thyroid stimulating hormone increased
Brain damage
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Depression
Drug abuser
Drug dependence
Drug ineffective

40-49:

Diabetes mellitus non-insulin-dependent
Diabetic coma
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Hypertension (high blood pressure)
Nephrolithiasis (calculi in the kidneys)
Rectal haemorrhage (bleeding from anus)
Increased appetite
Anxiety
Arthralgia (joint pain)
Bipolar disorder (mood disorder)

50-59:

Chills (felling of cold)
Constipation
Depression
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Eye pain
Hypertension (high blood pressure)
Incontinence (lack of moderation or self-control)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Neuralgia (pain in one or more nerves)

60+:

Asthenia (weakness)
Hypotension (abnormally low blood pressure)
Dyspnoea exertional (breathlessness or shortness of breath)
Ecchymosis (a discoloration of the skin resulting from bleeding underneath)
Fatigue (feeling of tiredness)
Nausea (feeling of having an urge to vomit)
Ocular rosacea (redness, irritation or burning of the eyes)
Pleural effusion (water on the lungs)
Pneumonia
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)

What are the existing conditions these people have? *

Pain: 11 people, 22.00%
Depression: 7 people, 14.00%
Neuralgia (pain in one or more nerves): 4 people, 8.00%
Stress And Anxiety: 3 people, 6.00%
Sleep Disorder: 3 people, 6.00%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 6.00%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 6.00%
High Blood Pressure: 3 people, 6.00%
Bipolar Disorder (mood disorder): 3 people, 6.00%

* Approximation only. Some reports may have incomplete information.

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