Florinef and Hyzaar drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Florinef (fludrocortisone acetate) and Hyzaar (hydrochlorothiazide; losartan potassium). Common drug interactions include anhedonia among males.

The phase IV clinical study analyzes what interactions people have when they take Florinef and Hyzaar. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Florinef?

Florinef has active ingredients of fludrocortisone acetate. It is often used in addison's disease. eHealthMe is studying from 3,834 Florinef users. Check the latest studies of Florinef.

What is Hyzaar?

Hyzaar has active ingredients of hydrochlorothiazide; losartan potassium. It is often used in high blood pressure. eHealthMe is studying from 16,614 Hyzaar users. Check the latest studies of Hyzaar.

On Jul, 13, 2026

16 people who take Florinef and Hyzaar together, and have interactions are studied.

What are the common drug interactions of Florinef and Hyzaar, by gender? *:

female:

n/a

male:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Depression
Diarrhoea
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Enteritis (inflammation of the small intestine)
Fatigue (feeling of tiredness)
Gastroenteritis radiation (radiation induced inflammation of stomach and intestine)
Haemoglobin decreased
Horner's syndrome (horner syndrome is a disorder that affects the eye and surrounding tissues on one side of the face and results from paralysis of certain nerves)

What are the common drug interactions of Florinef and Hyzaar, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Chest pain
Confusional state
Depression
Diarrhoea
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Enteritis (inflammation of the small intestine)
Fatigue (feeling of tiredness)
Gastroenteritis radiation (radiation induced inflammation of stomach and intestine)
Haemoglobin decreased
Horner's syndrome (horner syndrome is a disorder that affects the eye and surrounding tissues on one side of the face and results from paralysis of certain nerves)

60+:

Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Chest pain
Confusional state
Depression
Diarrhoea
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Enteritis (inflammation of the small intestine)
Erectile dysfunction
Fatigue (feeling of tiredness)

What are the existing conditions these people have? *

Prostate Cancer: 16 people, 100.00%
Bone Density Abnormal: 15 people, 93.75%
Pain: 14 people, 87.50%

* Approximation only. Some reports may have incomplete information.

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