Florinef and Macrobid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Florinef (fludrocortisone acetate) and Macrobid (nitrofurantoin; nitrofurantoin, macrocrystalline). Common drug interactions include anxiety among females and dizziness among males.

The phase IV clinical study analyzes what interactions people have when they take Florinef and Macrobid. It is created by eHealthMe based on reports of 32 people who take the same drugs from the FDA, and is updated regularly.

What is Florinef?

Florinef has active ingredients of fludrocortisone acetate. It is often used in addison's disease. eHealthMe is studying from 3,834 Florinef users. Check the latest studies of Florinef.

What is Macrobid?

Macrobid has active ingredients of nitrofurantoin; nitrofurantoin, macrocrystalline. It is often used in urinary tract infection. eHealthMe is studying from 9,215 Macrobid users. Check the latest studies of Macrobid.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 24, 2026

32 people who take Florinef and Macrobid together, and have interactions are studied.

Florinef and Macrobid drug interactions.

What are the common drug interactions of Florinef and Macrobid, by gender? *:

female:

Anxiety
Asthenia (weakness)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Bone disorder
Deafness
Dyspepsia (indigestion)
Dysphagia (a condition in which swallowing is difficult or painful)
Dyspnoea exertional (breathlessness or shortness of breath)
Ear pain
Fall

male:

Dizziness
Heart rate increased
Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)

What are the common drug interactions of Florinef and Macrobid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Drug hypersensitivity
Rash

30-39:

Cholecystitis chronic (long lasting infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Cystitis interstitial (unknown cause characterized by bladder pain)
Supraventricular tachycardia (rapid heart rhythm originating at or above the atrioventricular node)

40-49:

Dizziness
Heart rate increased
Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)

50-59:

Asthenia (weakness)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Bone disorder
Deafness
Depression
Dyspepsia (indigestion)
Dysphagia (a condition in which swallowing is difficult or painful)
Dyspnoea exertional (breathlessness or shortness of breath)
Ear pain
Fall

60+:

Gout (uric acid crystals building up in the body)
Haemorrhagic stroke (stroke caused by the rupture of a blood vessel in the brain)
Hypertensive crisis
Lethargy (tiredness)
Pain in extremity
Supraventricular extrasystoles (premature electrical impulse in the heart, generated above the level of the ventricle)

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 12 people, 37.50%
Light Chain Analysis Increased: 12 people, 37.50%
Neoplasm Malignant (cancer tumour): 6 people, 18.75%
Stress And Anxiety: 3 people, 9.38%
Secondary Immunodeficiency (lack of immunity due to some disease): 3 people, 9.38%
Polycystic Ovary Disease (cysts in the ovaries that occurs when the follicle stops developing): 2 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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