Floxin and Aldactone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Floxin (ofloxacin) and Aldactone (spironolactone). Common drug interactions include failure to thrive among females and pneumonia among males.

The phase IV clinical study analyzes what interactions people have when they take Floxin and Aldactone. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Floxin?

Floxin has active ingredients of ofloxacin. eHealthMe is studying from 1,737 Floxin users. Check the latest studies of Floxin.

What is Aldactone?

Aldactone has active ingredients of spironolactone. It is often used in acne. eHealthMe is studying from 46,063 Aldactone users. Check the latest studies of Aldactone.

On Aug, 02, 2026

12 people who take Floxin and Aldactone together, and have interactions are studied.

What are the common drug interactions of Floxin and Aldactone, by gender? *:

female:

Failure to thrive (inadequate weight gain and physical growth in children)
Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition)
Nausea (feeling of having an urge to vomit)
Rash
Stomatitis (inflammation of mucous membrane of mouth)
Swollen tongue (swelling of tongue)
Thyroid disorder (thyroid diseases)
Vomiting
Alanine aminotransferase increased
Aphasia (damage to the parts of the brain that control language)

male:

Pneumonia
Fall
Chest pain
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Colitis (inflammation of colon)
Constipation
Cough
Dehydration (dryness resulting from the removal of water)
Dyspnoea (difficult or laboured respiration)
Electrocardiogram st-t change

What are the common drug interactions of Floxin and Aldactone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Alanine aminotransferase increased
Aspartate aminotransferase increased
Failure to thrive (inadequate weight gain and physical growth in children)

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Hypoglycaemia (deficiency of glucose in the bloodstream)

50-59:

Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure)
Hepatic failure (liver failure)
Hepatic neoplasm malignant (liver cancer)
Liver fatty (fat deposition of liver)
Metastases to large intestine (cancer spreads to large intestine)
Peritonitis (inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs)
Renal impairment (severely reduced kidney function)

60+:

Pneumonia
Fall
Chest pain
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Colitis (inflammation of colon)
Constipation
Cough
Dehydration (dryness resulting from the removal of water)
Dyspnoea (difficult or laboured respiration)
Electrocardiogram st-t change

What are the existing conditions these people have? *

Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 4 people, 33.33%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 3 people, 25.00%
Diabetes: 2 people, 16.67%
Urinary Tract Infection: 1 person, 8.33%
Type 2 Diabetes: 1 person, 8.33%
Raynaud's Phenomenon (discoloration of the fingers, toes, and occasionally other areas): 1 person, 8.33%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 1 person, 8.33%
Oedema Peripheral (superficial swelling): 1 person, 8.33%
Interstitial Lung Disease: 1 person, 8.33%
High Blood Pressure: 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Floxin and Aldactone?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously