Fluconazole and Excedrin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Fluconazole (fluconazole) and Excedrin (acetaminophen; aspirin; caffeine). Common drug interactions include anogenital warts among females and pulmonary embolism among males.

The phase IV clinical study analyzes what interactions people have when they take Fluconazole and Excedrin. It is created by eHealthMe based on reports of 83 people who take the same drugs from the FDA, and is updated regularly.

What is Fluconazole?

Fluconazole has active ingredients of fluconazole. It is often used in vaginal yeast infection. eHealthMe is studying from 70,481 Fluconazole users. Check the latest studies of Fluconazole.

What is Excedrin?

Excedrin has active ingredients of acetaminophen; aspirin; caffeine. It is often used in headache. eHealthMe is studying from 22,740 Excedrin users. Check the latest studies of Excedrin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 24, 2026

83 people who take Fluconazole and Excedrin together, and have interactions are studied.

Fluconazole and Excedrin drug interactions.

What are the common drug interactions of Fluconazole and Excedrin, by gender? *:

female:

Anogenital warts
Blood hiv rna increased
Depression
Kidney infection
Nausea (feeling of having an urge to vomit)
Urinary tract infection
Viral load increased
Aphasia (damage to the parts of the brain that control language)
Dyspnoea (difficult or laboured respiration)
Emotional distress

male:

Pulmonary embolism (blockage of the main artery of the lung)
Anxiety
Cholecystitis (infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dyspnoea (difficult or laboured respiration)
Emotional distress
General physical health deterioration (weak health status)
Mobility decreased (ability to move is reduced)

What are the common drug interactions of Fluconazole and Excedrin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Activated partial thromboplastin time prolonged
Aggression
Agitation (state of anxiety or nervous excitement)
Anaemia (lack of blood)
Anxiety
Bacterial infection
Blood magnesium decreased
Blood sodium decreased
Central line infection (infection by central line in icu)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)

30-39:

Fatigue (feeling of tiredness)
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Humerus fracture (injury to the upper arm bone)
Multiple fractures
Tooth loss
Upper limb fracture
Urinary tract infection
Viral infection
Vulval cellulitis (inflammation of skin around vagina)
Wheezing (a high-pitched whistling sound made while you breath)

40-49:

Cholecystitis (infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Abdominal pain upper
Gallbladder disorder
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Anxiety
Dyspnoea (difficult or laboured respiration)
Emotional distress
General physical health deterioration (weak health status)
Mobility decreased (ability to move is reduced)

50-59:

Pulmonary embolism (blockage of the main artery of the lung)
Chronic kidney disease
Death
Hepatic failure (liver failure)
Renal failure (kidney dysfunction)
Anxiety
Cholecystitis (infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)

60+:

Agraphia (a loss of the ability to write or to express thoughts in writing because of a brain lesion)
Alopecia (absence of hair from areas of the body)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Communication disorder (speech and language disorder)
Dysarthria (speech disorder)
Embolism arterial (blood clot that has travelled through your arteries and become stuck)
Hemiparesis (weakness on one side of the body)
Hemiplegia (paralysis of one side of the body)
Ischaemic stroke (stroke; caused by an interruption in the flow of blood to the brain)
Joint swelling

What are the existing conditions these people have? *

Migraine (headache): 14 people, 16.87%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 13 people, 15.66%
Pain: 11 people, 13.25%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 11 people, 13.25%
Birth Control: 10 people, 12.05%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 9 people, 10.84%
Stress And Anxiety: 8 people, 9.64%
Hiv Infection: 7 people, 8.43%
Premenstrual Syndrome: 6 people, 7.23%
Nausea (feeling of having an urge to vomit): 5 people, 6.02%

* Approximation only. Some reports may have incomplete information.

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