Fluconazole and Keytruda drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Fluconazole (fluconazole) and Keytruda (pembrolizumab). Common drug interactions include drug ineffective among females and anaemia among males.

The phase IV clinical study analyzes what interactions people have when they take Fluconazole and Keytruda. It is created by eHealthMe based on reports of 88 people who take the same drugs from the FDA, and is updated regularly.

What is Fluconazole?

Fluconazole has active ingredients of fluconazole. It is often used in vaginal yeast infection. eHealthMe is studying from 70,481 Fluconazole users. Check the latest studies of Fluconazole.

What is Keytruda?

Keytruda has active ingredients of pembrolizumab. It is often used in renal cell carcinoma. eHealthMe is studying from 57,404 Keytruda users. Check the latest studies of Keytruda.

On Jul, 14, 2026

88 people who take Fluconazole and Keytruda together, and have interactions are studied.

Fluconazole and Keytruda drug interactions.

What are the common drug interactions of Fluconazole and Keytruda, by gender? *:

female:

Drug ineffective
Dry skin
Dysphagia (a condition in which swallowing is difficult or painful)
Dysphonia (speech disorder attributable to a disorder of phonation)
Eye pruritus (eye itching)
Fall
Gait disturbance
General physical health deterioration (weak health status)
Hyperkeratosis (thickening of the outer layer of the skin)
Localised infection (infection at the single location)

male:

Anaemia (lack of blood)
Histiocytosis haematophagic
Ileus (a painful obstruction of the ileum or other part of the intestine)
Malaise (a feeling of general discomfort or uneasiness)
Muscular weakness (muscle weakness)
Myelitis (infection or the inflammation of white matter or gray matter of spinal cord which is a part of central nervous system)
Urinary retention (the inability to completely or partially empty the bladder)
Hepatitis c
Arthralgia (joint pain)
Dysuria (painful or difficult urination)

What are the common drug interactions of Fluconazole and Keytruda, by age (0-1 to 60+)? *:

0-1:

Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)
Premature baby

2-9:

n/a

10-19:

n/a

20-29:

Swollen tongue (swelling of tongue)
Vomiting
Wheezing (a high-pitched whistling sound made while you breath)
Dizziness
Dyspnoea (difficult or laboured respiration)
Flushing (the warm, red condition of human skin)
Heart rate increased
Maternal exposure during pregnancy (use of substance during pregnancy)
Nausea (feeling of having an urge to vomit)
Premature delivery

30-39:

Blood creatinine increased
Prerenal failure
Renal failure (kidney dysfunction)

40-49:

n/a

50-59:

Meningitis (inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges)
Lichenoid keratosis (a skin disorder described by rapid growing, reddish to brown, benign (noncancerous) lesion on the skin)
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Hypertriglyceridaemia (excess of triglycerides in the blood)
Hepatitis c
Alanine aminotransferase increased
Ataxia (loss of full control of bodily movements)
Back pain
Catheter site haemorrhage (bleeding at catheter site)
Cns ventriculitis (inflammation of the ventricles in the brain)

60+:

Pneumonia
Pulmonary embolism (blockage of the main artery of the lung)
Mixed liver injury
Supraventricular tachycardia (rapid heart rhythm originating at or above the atrioventricular node)
Dysphonia (speech disorder attributable to a disorder of phonation)
Oral pain
Rash erythematous (redness of the skin)
Weight decreased
Arthralgia (joint pain)
Gait disturbance

What are the existing conditions these people have? *

Pneumonia: 25 people, 28.41%
Non-Small Cell Lung Cancer Stage 0: 24 people, 27.27%
Insomnia (sleeplessness): 12 people, 13.64%
Lung Cancer - Non-Small Cell (lung cancer): 11 people, 12.50%
High Blood Pressure: 11 people, 12.50%
Prostatitis (inflammation of the prostate gland): 9 people, 10.23%
Pain: 9 people, 10.23%
Lung Adenocarcinoma (a form of non-small cell lung cancer): 9 people, 10.23%
Lung Neoplasm Malignant (cancer tumour of lung): 5 people, 5.68%
Diabetes: 5 people, 5.68%

* Approximation only. Some reports may have incomplete information.

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