Fluconazole and Periogard drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Fluconazole (fluconazole) and Periogard (chlorhexidine gluconate). Common drug interactions include hypovolaemia among females and anaemia among males.

The phase IV clinical study analyzes what interactions people have when they take Fluconazole and Periogard. It is created by eHealthMe based on reports of 34 people who take the same drugs from the FDA, and is updated regularly.

What is Fluconazole?

Fluconazole has active ingredients of fluconazole. It is often used in vaginal yeast infection. eHealthMe is studying from 70,481 Fluconazole users. Check the latest studies of Fluconazole.

What is Periogard?

Periogard has active ingredients of chlorhexidine gluconate. eHealthMe is studying from 3,814 Periogard users. Check the latest studies of Periogard.

On Jul, 29, 2026

34 people who take Fluconazole and Periogard together, and have interactions are studied.

Fluconazole and Periogard drug interactions.

What are the common drug interactions of Fluconazole and Periogard, by gender? *:

female:

Hypovolaemia (a decreased volume of circulating blood in the body)
Ichthyosis (genetic skin disorders)
Impaired healing
Inflammation
Jaw fracture
Joint effusion (presence of extra fluid in joint covering)
Loose tooth
Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)
Mitral valve prolapse (heart's mitral valve doesn't work well)
Mucosal inflammation (infection of mucous membrane)

male:

Anaemia (lack of blood)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Aspartate aminotransferase increased
Atelectasis (partial or complete collapse of the lung)
Blood bicarbonate increased
Blood bilirubin increased
Blood chloride decreased
Blood fibrinogen increased
Blood ph increased
Blood sodium decreased

What are the common drug interactions of Fluconazole and Periogard, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Thrombocytopenia (decrease of platelets in blood)
Troponin i increased
Pyrexia (fever)
Abdominal pain
Abdominal pain upper
Actinomycosis (infection that causes sores, or abscesses)
Angiopathy (generic term for a disease of the blood vessels)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Arthritis (form of joint disorder that involves inflammation of one or more joints)

50-59:

Bone density decreased
Cough
Nausea (feeling of having an urge to vomit)
Pyrexia (fever)
Anxiety
Constipation
Fall
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Oedema peripheral (superficial swelling)
Osteonecrosis of jaw (death of bone of jaw)

60+:

Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Radius fracture
Vena cava thrombosis (clotting of the blood in large vein carrying deoxygenated blood into the heart)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 21 people, 61.76%
High Blood Pressure: 15 people, 44.12%
Multiple Myeloma (cancer of the plasma cells): 14 people, 41.18%
Fatigue (feeling of tiredness): 14 people, 41.18%
Metastases To Bone (cancer spreads to bone): 12 people, 35.29%
Breast Cancer: 12 people, 35.29%
Bone Cancer Metastatic: 12 people, 35.29%
Pain: 7 people, 20.59%
White Blood Cell Count Abnormal: 6 people, 17.65%
Rashes (redness): 6 people, 17.65%

* Approximation only. Some reports may have incomplete information.

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