Fluconazole and Zenpep drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Fluconazole (fluconazole) and Zenpep (pancrelipase (amylase;lipase;protease)). Common drug interactions include mental status changes among females and hospitalisation among males.

The phase IV clinical study analyzes what interactions people have when they take Fluconazole and Zenpep. It is created by eHealthMe based on reports of 88 people who take the same drugs from the FDA, and is updated regularly.

What is Fluconazole?

Fluconazole has active ingredients of fluconazole. It is often used in vaginal yeast infection. eHealthMe is studying from 70,481 Fluconazole users. Check the latest studies of Fluconazole.

What is Zenpep?

Zenpep has active ingredients of pancrelipase (amylase;lipase;protease). eHealthMe is studying from 5,529 Zenpep users. Check the latest studies of Zenpep.

On Jul, 09, 2026

88 people who take Fluconazole and Zenpep together, and have interactions are studied.

Fluconazole and Zenpep drug interactions.

What are the common drug interactions of Fluconazole and Zenpep, by gender? *:

female:

Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Metastases to liver (cancer spreads to liver)
Metastasis (spreadable cancer to other organ from origin)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Peritoneal haemorrhage (peritoneal bleeding)
Platelet count decreased
Prostate cancer metastatic
Pseudomonas infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa)
Respiration (transport of oxygen from the outside air to the cells within tissues)

male:

Hospitalisation
Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)
Cystic fibrosis related diabetes
Death
Gastrointestinal inflammation (inflammation of stomach and intestine)
Hepatic enzyme increased
Hypoxia (low oxygen in tissues)
Infection
Infective exacerbation of bronchiectasis (severe infective lung disease)
Lung infection

What are the common drug interactions of Fluconazole and Zenpep, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Headache (pain in head)
Musculoskeletal chest pain (pain in chest muscle or nerve or bones)
Sputum increased
Weight decreased
Infection
Urine cannabinoids increased
Hepatic enzyme increased
Herpangina (mouth blisters)
Hospitalisation
Pulmonary function test decreased

20-29:

Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)
Lung transplant
Pain in extremity
Bronchiectasis (abnormal widening of the bronchi or their branches, causing a risk of infection)
Cystic fibrosis pancreatic (fibrosis with cyst in the pancreas)
Cystic fibrosis related diabetes
Death
Distal intestinal obstruction syndrome (blockage of the intestines by thickened stool and occurs in individuals with cystic fibrosis)
Drug hypersensitivity
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)

30-39:

Diarrhoea
Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)
Asthenia (weakness)
Chronic kidney disease
Coccidioidomycosis (serious disease of the lungs and other tissues, caused by the fungus coccidioides immitis)
Dizziness
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Flatulence (flatus expelled through the anus)
Gastrointestinal disorder (functional problems of gastrointestinal tract)

40-49:

Adverse drug reaction
Cough
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Emotional disorder
Flatulence (flatus expelled through the anus)
Lung infection
Pain of skin
Pruritus (severe itching of the skin)
Sunburn

50-59:

Chronic kidney disease
Renal failure (kidney dysfunction)
Anxiety
Cellulitis (infection under the skin)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Influenza
Jaundice cholestatic
Lung infection
Pancreatic carcinoma (pancreatic cancer)
Pancreatitis (inflammation of pancreas)

60+:

Chronic kidney disease
Renal tubular necrosis (death of kidney tubules)
Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle)
Klebsiella sepsis (klebsiella causes a potentially fatal whole-body inflammation)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Peritoneal haemorrhage (peritoneal bleeding)
Platelet count decreased
Tooth abscess (pus formation in tooth)
Tooth fracture

What are the existing conditions these people have? *

Cystic Fibrosis (disease of the secretary glands): 45 people, 51.14%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 24 people, 27.27%
Diabetes: 19 people, 21.59%
High Blood Pressure: 19 people, 21.59%
Cough: 19 people, 21.59%
Fungal Infection: 18 people, 20.45%
Nausea (feeling of having an urge to vomit): 18 people, 20.45%
High Blood Cholesterol: 17 people, 19.32%
Constipation: 15 people, 17.05%
Depression: 14 people, 15.91%

* Approximation only. Some reports may have incomplete information.

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