Fludara and Gazyva drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Fludara (fludarabine phosphate) and Gazyva (obinutuzumab). Common drug interactions include hypersensitivity among females and drug ineffective among males.

The phase IV clinical study analyzes what interactions people have when they take Fludara and Gazyva. It is created by eHealthMe based on reports of 53 people who take the same drugs from the FDA, and is updated regularly.

What is Fludara?

Fludara has active ingredients of fludarabine phosphate. eHealthMe is studying from 46,686 Fludara users. Check the latest studies of Fludara.

What is Gazyva?

Gazyva has active ingredients of obinutuzumab. eHealthMe is studying from 4,470 Gazyva users. Check the latest studies of Gazyva.

On Jul, 28, 2026

53 people who take Fludara and Gazyva together, and have interactions are studied.

What are the common drug interactions of Fludara and Gazyva, by gender? *:

female:

Hypersensitivity
Hyperthermia (body temperature greatly above normal)
Hypoaesthesia (reduced sense of touch or sensation)
Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection)
Immune thrombocytopenic purpura (destruction of blood platelets due to the presence of antiplatelet auto antibodies)
Influenza
Infusion related reaction
Joint swelling
Lymphadenopathy (disease or enlargement of lymph nodes)
Mouth ulceration (mouth ulcers)

male:

Drug ineffective
Myelosuppression (a decrease in the production of blood cells)
Lymphadenopathy (disease or enlargement of lymph nodes)
Neutropenia (an abnormally low number of neutrophils)
Infusion related reaction
Tumour lysis syndrome (a group of metabolic complications that can occur after treatment of cancer, these complications are caused by the breakdown products of dying cancer cells)
Abdominal distension
Blood fibrinogen decreased
Blood triglycerides increased
Bone marrow toxicity (decrease in cells responsible for providing immunity, carrying oxygen, and those responsible for normal blood clotting)

What are the common drug interactions of Fludara and Gazyva, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Sinus bradycardia (an unusually slow heartbeat due to heart disease)
Disease progression
Drug ineffective
Drug resistance (reduction in effectiveness of a drug)
Infusion related reaction
Pneumonia
Traumatic lung injury
Chest discomfort
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Hypersensitivity

40-49:

Cytomegalovirus chorioretinitis (infection of choroid and retina of the eye from virus)
Cytomegalovirus colitis (an inflammation of the colon from virus)
Cytomegalovirus infection
Dyspnoea (difficult or laboured respiration)
Pneumonia cytomegaloviral (cmv pneumonia is caused by a member of a group of herpes-type viruses)
Pyrexia (fever)
Nausea (feeling of having an urge to vomit)
Chronic lymphocytic leukaemia recurrent (repeated cancer of blood cells known as lymphocytes)
Encephalitis viral (inflammation of the brain due to viral infection)
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)

50-59:

Myelosuppression (a decrease in the production of blood cells)
Drug ineffective
Pyrexia (fever)
Disease recurrence
Herpes zoster
Proctitis infectious (inflammation of the rectum and anus by infection)
Secondary immunodeficiency (lack of immunity due to some disease)
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries)
Interstitial lung disease

60+:

White blood cell count decreased
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Hypoproteinaemia (too little prolactin circulating in the blood)
Lymphocyte count decreased
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Peritonitis (inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs)
Platelet count decreased
Pneumonia
Procalcitonin increased
Serum ferritin increased

What are the existing conditions these people have? *

Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 26 people, 49.06%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 13 people, 24.53%
Burkitt Lymphoma (cancer of the lymphatic system): 9 people, 16.98%
B-Cell Lymphoma Recurrent (blood cancer affecting b cells-recurrent): 3 people, 5.66%

* Approximation only. Some reports may have incomplete information.

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