Fludara and Lamotrigine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Fludara (fludarabine phosphate) and Lamotrigine (lamotrigine). Common drug interactions include pancytopenia among females and diaphragmatic disorder among males.

The phase IV clinical study analyzes what interactions people have when they take Fludara and Lamotrigine. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Fludara?

Fludara has active ingredients of fludarabine phosphate. eHealthMe is studying from 46,686 Fludara users. Check the latest studies of Fludara.

What is Lamotrigine?

Lamotrigine has active ingredients of lamotrigine. It is often used in bipolar disorder. eHealthMe is studying from 76,638 Lamotrigine users. Check the latest studies of Lamotrigine.

On Jul, 02, 2026

15 people who take Fludara and Lamotrigine together, and have interactions are studied.

Fludara and Lamotrigine drug interactions.

What are the common drug interactions of Fludara and Lamotrigine, by gender? *:

female:

Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
General physical health deterioration (weak health status)
Lung infection
Acute graft versus host disease (acute complication following an allogeneic tissue/blood transplant)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Cytomegalovirus infection
Encephalopathy (functioning of the brain is affected by some agent or condition)
Infarction (obstruction of the blood supply to an organ or region of tissue)

male:

Diaphragmatic disorder
Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)
Cerebral thrombosis (blood clot in brain)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chest pain
Cholecystitis chronic (long lasting infection of gallbladder)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Delirium (wild excitement)
Electrocardiogram qrs complex prolonged
Epstein-barr virus infection

What are the common drug interactions of Fludara and Lamotrigine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Acute graft versus host disease (acute complication following an allogeneic tissue/blood transplant)
Cytomegalovirus infection
Posterior reversible encephalopathy syndrome (posterior reversible encephalopathy syndrome (pres), also known as reversible posterior leukoencephalopathy syndrome (rpls), is a syndrome characterized by headache, confusion, seizures and visual loss)
Sepsis (a severe blood infection that can lead to organ failure and death)
Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)

20-29:

Agitation (state of anxiety or nervous excitement)
Delirium (wild excitement)
Electrocardiogram qrs complex prolonged
Foaming at mouth (excess saliva secretion)
Myoclonus (a brief, involuntary twitching of a muscle or a group of muscles)
Overdose
Tremor (trembling or shaking movements in one or more parts of your body)

30-39:

n/a

40-49:

n/a

50-59:

Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Infarction (obstruction of the blood supply to an organ or region of tissue)
Myelodysplastic syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged)
Myeloproliferative disorder (a group of diseases in which the bone marrow makes too many red blood cells, white blood cells, or platelets)
Progressive multifocal leukoencephalopathy (rapidly progressive neuromuscular disease caused by opportunistic infection of brain cells)
Renal failure (kidney dysfunction)

60+:

Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Splenomegaly (enlargement of spleen)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Cerebral thrombosis (blood clot in brain)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chest pain
Cholecystitis chronic (long lasting infection of gallbladder)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)

What are the existing conditions these people have? *

Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 7 people, 46.67%
Lymphopenia (an abnormally low level of lymphocytes in the blood): 3 people, 20.00%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 2 people, 13.33%
Infection: 2 people, 13.33%
Bone Marrow Conditioning Regimen: 2 people, 13.33%
Stress And Anxiety: 1 person, 6.67%
Sleep Disorder: 1 person, 6.67%
Posterior Reversible Encephalopathy Syndrome (posterior reversible encephalopathy syndrome (pres), also known as reversible posterior leukoencephalopathy syndrome (rpls), is a syndrome characterized by headache, confusion, seizures and visual loss): 1 person, 6.67%
Mood Swings (an extreme or rapid change in mood): 1 person, 6.67%
Herpes Virus Infection: 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

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