Fluoride and Bactrim drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Fluoride (fluoride) and Bactrim (sulfamethoxazole; trimethoprim). Common drug interactions include osteomyelitis among females and nausea among males.

The phase IV clinical study analyzes what interactions people have when they take Fluoride and Bactrim. It is created by eHealthMe based on reports of 64 people who take the same drugs from the FDA, and is updated regularly.

What is Fluoride?

Fluoride has active ingredients of fluoride. eHealthMe is studying from 2,301 Fluoride users. Check the latest studies of Fluoride.

What is Bactrim?

Bactrim has active ingredients of sulfamethoxazole; trimethoprim. It is often used in urinary tract infection. eHealthMe is studying from 89,117 Bactrim users. Check the latest studies of Bactrim.

On Jul, 13, 2026

64 people who take Fluoride and Bactrim together, and have interactions are studied.

What are the common drug interactions of Fluoride and Bactrim, by gender? *:

female:

Osteomyelitis (infection of bone)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Protein urine
Proteinuria (presence of protein in the urine)
Respiratory tract congestion (blockage on respiratory system)
Rosacea (a skin condition that causes facial redness)
Sinusitis (inflammation of sinus)
Streptococcal infection
Suicidal ideation
Tracheitis (an inflammation of the trachea)

male:

Nausea (feeling of having an urge to vomit)
Febrile neutropenia (fever with reduced white blood cells)
Arthralgia (joint pain)
Chronic graft versus host disease in skin (damage by immune cells to skin after grafting)
Cytomegalovirus test positive
Dental caries
Dermatitis acneiform (dermatoses including acne vulgaris, rosacea, folliculitis, and perioral dermatitis)
Dry mouth
Fall
Headache (pain in head)

What are the common drug interactions of Fluoride and Bactrim, by age (0-1 to 60+)? *:

0-1:

Human rhinovirus test positive
Pyrexia (fever)
Rash
Transaminases increased

2-9:

Acute lymphocytic leukaemia (cancer of the white blood cells)
Decreased activity
Pallor
Petechiae (a small red or purple spot caused by bleeding into the skin)
Cough
Dermatitis atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder)
Ear infection
Febrile neutropenia (fever with reduced white blood cells)
Hepatic enzyme increased
Pyrexia (fever)

10-19:

Asthenia (weakness)
Constipation
Febrile neutropenia (fever with reduced white blood cells)
Haemoglobin decreased
Pyrexia (fever)

20-29:

n/a

30-39:

Acute graft versus host disease (acute complication following an allogeneic tissue/blood transplant)
Anaemia (lack of blood)
Anxiety
Back pain
Chronic graft versus host disease (immune cells attack the host's body cells after transplant)
Chronic graft versus host disease in skin (damage by immune cells to skin after grafting)
Constipation
Cytomegalovirus test positive
Dental caries
Dermatitis acneiform (dermatoses including acne vulgaris, rosacea, folliculitis, and perioral dermatitis)

40-49:

Abdominal pain
Diarrhoea
Hysterectomy
Malignant neoplasm progression (cancer tumour came back)
Metastases to bone (cancer spreads to bone)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
White blood cell count decreased
Wound

50-59:

Abdominal distension
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Hepatic steatosis (fatty liver disease)
Postoperative wound infection
Ill-defined disorder
Malaise (a feeling of general discomfort or uneasiness)
Neuropathy peripheral (surface nerve damage)
Small intestinal perforation (hole in small intestine)
Small intestine gangrene (small intestine tissue dies)

60+:

Death
Arthralgia (joint pain)
Febrile neutropenia (fever with reduced white blood cells)
Gait disturbance
Herpes zoster
Hyperkalaemia (damage to or disease of the kidney)
Lymphocyte count decreased
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Muscular weakness (muscle weakness)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 11 people, 17.19%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 8 people, 12.50%
Dermatitis Atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder): 5 people, 7.81%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 5 people, 7.81%
Immunodeficiency Common Variable: 4 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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