Fluoride and Compazine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Fluoride (fluoride) and Compazine (prochlorperazine maleate). Common drug interactions include osteoradionecrosis among females and hyponatraemia among males.

The phase IV clinical study analyzes what interactions people have when they take Fluoride and Compazine. It is created by eHealthMe based on reports of 29 people who take the same drugs from the FDA, and is updated regularly.

What is Fluoride?

Fluoride has active ingredients of fluoride. eHealthMe is studying from 2,301 Fluoride users. Check the latest studies of Fluoride.

What is Compazine?

Compazine has active ingredients of prochlorperazine maleate. It is often used in indigestion. eHealthMe is studying from 13,646 Compazine users. Check the latest studies of Compazine.

On Jul, 12, 2026

29 people who take Fluoride and Compazine together, and have interactions are studied.

Fluoride and Compazine drug interactions.

What are the common drug interactions of Fluoride and Compazine, by gender? *:

female:

Osteoradionecrosis (irradiation of bones causes damage to osteocytes and impairs the blood supply)
Pain
Pathological fracture (broken bone caused by disease)
Pneumonia
Febrile neutropenia (fever with reduced white blood cells)
Upper respiratory tract infection
Diarrhoea
Lymphadenopathy (disease or enlargement of lymph nodes)
Pneumonitis (inflammation of the walls of the alveoli in the lungs)
Pseudomonal sepsis (pseudomonas infections are diseases caused by a bacterium from the genus pseudomonas)

male:

Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Bronchopulmonary aspergillosis (lung disorder caused by aspergillus fungi)
Maternal exposure during pregnancy (use of substance during pregnancy)
Monoclonal immunoglobulin present
Oedema (fluid collection in tissue)
Pain
Pneumonia
Premature baby
Chest pain
Death

What are the common drug interactions of Fluoride and Compazine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Pneumonitis (inflammation of the walls of the alveoli in the lungs)
Flank pain (a distressing sensation experienced around the lower back and the upper abdomen)
Febrile neutropenia (fever with reduced white blood cells)
Mucosal inflammation (infection of mucous membrane)

40-49:

Bone pain
Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle)

50-59:

Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Pneumonia
Bronchopulmonary aspergillosis (lung disorder caused by aspergillus fungi)
Chest pain
Inappropriate antidiuretic hormone secretion

60+:

Febrile neutropenia (fever with reduced white blood cells)
Pneumonia
Diastolic dysfunction
Eating disorder
Lymphadenopathy (disease or enlargement of lymph nodes)
Metastases to lung (cancer spreads to lung)
Migraine (headache)
Nocturia (the need to get up in the night to urinate)
Pleural effusion (water on the lungs)
Pruritus (severe itching of the skin)

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 8 people, 27.59%
Pain: 5 people, 17.24%
Headache (pain in head): 4 people, 13.79%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 4 people, 13.79%
Renal Cell Carcinoma (a kidney cancer): 3 people, 10.34%
Hodgkin's Lymphoma (cancer originating from white blood cells): 3 people, 10.34%
Diarrhea: 3 people, 10.34%
Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 3 people, 10.34%
Acute Lymphocytic Leukaemia Recurrent (cancer in which the bone marrow makes too many lymphocytes-recurrent): 3 people, 10.34%
Nausea (feeling of having an urge to vomit): 2 people, 6.90%

* Approximation only. Some reports may have incomplete information.

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