Fluorouracil and Dapsone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Fluorouracil (fluorouracil) and Dapsone (dapsone). Common drug interactions include gastrointestinal disorder among females and anhedonia among males.

The phase IV clinical study analyzes what interactions people have when they take Fluorouracil and Dapsone. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Fluorouracil?

Fluorouracil has active ingredients of fluorouracil. It is often used in colon cancer metastatic. eHealthMe is studying from 97,087 Fluorouracil users. Check the latest studies of Fluorouracil.

What is Dapsone?

Dapsone has active ingredients of dapsone. It is often used in dermatitis herpetiformis. eHealthMe is studying from 11,732 Dapsone users. Check the latest studies of Dapsone.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 16, 2026

15 people who take Fluorouracil and Dapsone together, and have interactions are studied.

Fluorouracil and Dapsone drug interactions.

What are the common drug interactions of Fluorouracil and Dapsone, by gender? *:

female:

Gastrointestinal disorder (functional problems of gastrointestinal tract)
Drug ineffective
Methaemoglobinaemia (a disorder characterized by the presence of a higher than normal level of methemoglobin in blood)
Dermatitis allergic (inflammation of the skin due allergic reaction)
Pruritus (severe itching of the skin)
Therapeutic response decreased (less preventive response)
Anaemia (lack of blood)
Leukopenia (less number of white blood cells in blood)
Nausea (feeling of having an urge to vomit)
Neutropenia (an abnormally low number of neutrophils)

male:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Renal failure (kidney dysfunction)
Rotator cuff repair
Spinal cord injury
Upper limb fracture
Aortic aneurysm (enlargement of an aortic artery caused by a weakening of the artery wall)
Arteriovenous malformation
Fracture
Pneumonia

What are the common drug interactions of Fluorouracil and Dapsone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Anaemia (lack of blood)
Angioedema (rapid swelling of the dermis)
Cataract (clouding of the lens inside the eye)
Cd4 lymphocytes decreased
Chest discomfort
Fatigue (feeling of tiredness)
Leukopenia (less number of white blood cells in blood)
Lower respiratory tract infection
Nausea (feeling of having an urge to vomit)
Neutropenia (an abnormally low number of neutrophils)

30-39:

n/a

40-49:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Bone density decreased
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Chronic kidney disease
Emotional distress
Hip arthroplasty
Osteopenia (a condition where bone mineral density is lower than normal)
Osteoporosis (bones weak and more likely to break)
Pain

50-59:

Gastrointestinal disorder (functional problems of gastrointestinal tract)
Drug ineffective
Methaemoglobinaemia (a disorder characterized by the presence of a higher than normal level of methemoglobin in blood)
Dermatitis allergic (inflammation of the skin due allergic reaction)
Pruritus (severe itching of the skin)
Therapeutic response decreased (less preventive response)

60+:

Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Pneumonia
Skin lesion

What are the existing conditions these people have? *

Granuloma Skin (a small area of inflammation on skin due to tissue injury): 4 people, 26.67%
Hyperkalemia (damage to or disease of the kidney): 3 people, 20.00%
Hiv Infection: 3 people, 20.00%
Angiolymphoid Hyperplasia With Eosinophilia (uncommon idiopathic condition that manifests in adults as isolated or grouped papules, plaques, or nodules in the skin of the head and neck): 2 people, 13.33%
Pain: 1 person, 6.67%
Oral Cancer (mouth cancer): 1 person, 6.67%
Necrotising Retinitis (life threatening infection of retina): 1 person, 6.67%
Cystic Fibrosis Lung (fibrosis with cyst in the lung): 1 person, 6.67%
Behcet's Syndrome (involves inflammation of the blood vessels): 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

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