Fluoxetine and Drospirenone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Fluoxetine (fluoxetine hydrochloride) and Drospirenone (drospirenone). Common drug interactions include body dysmorphic disorder among females.

The phase IV clinical study analyzes what interactions people have when they take Fluoxetine and Drospirenone. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Fluoxetine?

Fluoxetine has active ingredients of fluoxetine hydrochloride. It is often used in depression. eHealthMe is studying from 98,823 Fluoxetine users. Check the latest studies of Fluoxetine.

What is Drospirenone?

Drospirenone has active ingredients of drospirenone. eHealthMe is studying from 602 Drospirenone users. Check the latest studies of Drospirenone.

On Jul, 16, 2026

20 people who take Fluoxetine and Drospirenone together, and have interactions are studied.

Fluoxetine and Drospirenone drug interactions.

What are the common drug interactions of Fluoxetine and Drospirenone, by gender? *:

female:

Body dysmorphic disorder (type of mental illness)
Agitation (state of anxiety or nervous excitement)
Weight increased
Nausea (feeling of having an urge to vomit)
Vomiting
Judgement impaired
Scar
Diarrhoea
Joint swelling
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)

male:

n/a

What are the common drug interactions of Fluoxetine and Drospirenone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Body dysmorphic disorder (type of mental illness)
Agitation (state of anxiety or nervous excitement)
Hyperphagia (an abnormal appetite for food)
Hypersexuality
Impulse-control disorder
Intentional self-injury
Oropharyngeal pain
Personality change
Suicidal ideation
Theft

20-29:

Adverse event
Anal fissure
Fatigue (feeling of tiredness)
Headache (pain in head)
Rectal abscess (pus in rectum)
Thrombosis (formation of a blood clot inside a blood vessel)
Joint swelling
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Polycystic ovaries (cysts in the ovaries that occurs when the follicle stops developing)
Abdominal discomfort

30-39:

Injection site erythema (redness at injection site)
Injection site swelling
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Rash
Sleep disorder
Upper respiratory tract infection

40-49:

n/a

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

Stress And Anxiety: 9 people, 45.00%
Depressed Mood: 9 people, 45.00%
Autism Spectrum Disorder (developmental disabilities that can cause significant social, communication and behavioural challenges): 9 people, 45.00%
Agitation (state of anxiety or nervous excitement): 2 people, 10.00%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 1 person, 5.00%
Psoriasis (immune-mediated disease that affects the skin): 1 person, 5.00%
Neurodermatitis (a skin disorder characterized by long lasting itching and scratching): 1 person, 5.00%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 1 person, 5.00%
Diabetes: 1 person, 5.00%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

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