Focalin and Fluoxetine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Focalin (dexmethylphenidate hydrochloride) and Fluoxetine (fluoxetine hydrochloride). Common drug interactions include cholelithiasis among females and drug ineffective among males.

The phase IV clinical study analyzes what interactions people have when they take Focalin and Fluoxetine. It is created by eHealthMe based on reports of 64 people who take the same drugs from the FDA, and is updated regularly.

What is Focalin?

Focalin has active ingredients of dexmethylphenidate hydrochloride. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 4,781 Focalin users. Check the latest studies of Focalin.

What is Fluoxetine?

Fluoxetine has active ingredients of fluoxetine hydrochloride. It is often used in depression. eHealthMe is studying from 98,826 Fluoxetine users. Check the latest studies of Fluoxetine.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 04, 2026

64 people who take Focalin and Fluoxetine together, and have interactions are studied.

Focalin and Fluoxetine drug interactions.

What are the common drug interactions of Focalin and Fluoxetine, by gender? *:

female:

Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Constipation
Diarrhoea
Mania (a state of abnormally elevated or irritable mood)
Psychotic disorder
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)
Weight decreased
Abdominal distension
Abnormal behaviour
Adverse drug reaction

male:

Drug ineffective
Blood pressure diastolic decreased
Sinusitis (inflammation of sinus)
Underweight
Weight gain poor
Weight increased
Somnolence (a state of near-sleep, a strong desire for sleep)
Abnormal behaviour
Emotional distress
Gynaecomastia (enlargement of the gland tissue of the male breast)

What are the common drug interactions of Focalin and Fluoxetine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Ear pain
Eating disorder
Hypoaesthesia (reduced sense of touch or sensation)
Oppositional defiant disorder (a childhood disorder described by the diagnostic and statistical manual of mental disorders)
Oropharyngeal pain
Pharyngitis (inflammation of the pharynx, causing a sore throat)
Sinusitis (inflammation of sinus)
Underweight
Weight gain poor
Aggression

10-19:

Abnormal behaviour
Disease recurrence
Injection site haemorrhage (bleeding from injection site)
Injection site pain
Therapeutic response unexpected
Weight increased
Chronic kidney disease
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hallucination, visual (seeing things that aren't there)
Renal failure (kidney dysfunction)

20-29:

Somnolence (a state of near-sleep, a strong desire for sleep)
Paradoxical drug reaction
Abdominal pain
Abdominal pain upper
Akathisia (a movement disorder characterized by a feeling of inner restlessness)
Biliary colic
Cholecystitis chronic (long lasting infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Cholesterosis (abnormal deposition of cholesterol in tissues)
Confusional state

30-39:

Nausea (feeling of having an urge to vomit)
Abdominal pain
Head discomfort
Headache (pain in head)
Dizziness
Ear infection
Fall
Fatigue (feeling of tiredness)
Gait disturbance
Gastrointestinal disorder (functional problems of gastrointestinal tract)

40-49:

n/a

50-59:

Euphoric mood (excessively happy but may become angry or irritable)
Hepatomegaly (abnormal enlargement of the liver)
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Somnolence (a state of near-sleep, a strong desire for sleep)
Urinary retention (the inability to completely or partially empty the bladder)
Blunted affect (lack of emotional reactivity)
Constipation
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Disturbance in attention

60+:

Asthma
Disease recurrence
Hot flush (sudden feelings of heat)
Irritable bowel syndrome

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 7 people, 10.94%
Immunodeficiency Common Variable: 6 people, 9.38%
Bipolar Disorder (mood disorder): 6 people, 9.38%
Stress And Anxiety: 4 people, 6.25%
Growth Hormone Deficiency: 4 people, 6.25%
Drowsiness: 4 people, 6.25%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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