Focalin and Methylphenidate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Focalin (dexmethylphenidate hydrochloride) and Methylphenidate (methylphenidate). Common drug interactions include lower limb fracture among females and drug ineffective among males.

The phase IV clinical study analyzes what interactions people have when they take Focalin and Methylphenidate. It is created by eHealthMe based on reports of 32 people who take the same drugs from the FDA, and is updated regularly.

What is Focalin?

Focalin has active ingredients of dexmethylphenidate hydrochloride. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 4,781 Focalin users. Check the latest studies of Focalin.

What is Methylphenidate?

Methylphenidate has active ingredients of methylphenidate. eHealthMe is studying from 8,216 Methylphenidate users. Check the latest studies of Methylphenidate.

On Jul, 11, 2026

32 people who take Focalin and Methylphenidate together, and have interactions are studied.

Focalin and Methylphenidate drug interactions.

What are the common drug interactions of Focalin and Methylphenidate, by gender? *:

female:

Lower limb fracture
Confusional state
Weight decreased
Fall
Memory impairment
Musculoskeletal discomfort (discomfort in the body's muscles, joints, tendons, ligaments and nerves)
Somnambulism (sleep walking)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Arthralgia (joint pain)
Back pain

male:

Drug ineffective
Dehydroepiandrosterone increased
Abnormal behaviour
Aggression
Abdominal pain
Agitation (state of anxiety or nervous excitement)
Alcaligenes infection (infection by bacteria alcaligenes)
Cystic fibrosis (disease of the secretary glands)
Depressed mood
Dysphagia (a condition in which swallowing is difficult or painful)

What are the common drug interactions of Focalin and Methylphenidate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Drug ineffective
Abnormal behaviour
Agitation (state of anxiety or nervous excitement)
Dysphagia (a condition in which swallowing is difficult or painful)

10-19:

Drug ineffective
Dehydroepiandrosterone increased
Injection site extravasation (flow of (blood or lymph) from injection site)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Cerebral haemorrhage (bleeding within the brain)
Headache (pain in head)
Hypersomnia (excessive daytime sleepiness (eds))
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Pyrexia (fever)
Vomiting

20-29:

n/a

30-39:

Abnormal sleep-related event
Weight decreased

40-49:

Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)
Lower limb fracture
Restlessness (not able to rest)

50-59:

Knee arthroplasty

60+:

Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Arthralgia (joint pain)
Back pain
Chronic kidney disease
Confusional state
Therapeutic response unexpected
Weight decreased

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 10 people, 31.25%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 8 people, 25.00%
Oppositional Defiant Disorder (a childhood disorder described by the diagnostic and statistical manual of mental disorders): 4 people, 12.50%
Hypersensitivity: 4 people, 12.50%
Growth Hormone Deficiency: 4 people, 12.50%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 9.38%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 2 people, 6.25%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 6.25%
Cystic Fibrosis (disease of the secretary glands): 2 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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