Focalin and Periactin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Focalin (dexmethylphenidate hydrochloride) and Periactin (cyproheptadine hydrochloride). Common drug interactions include nausea among females and irritability among males.

The phase IV clinical study analyzes what interactions people have when they take Focalin and Periactin. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Focalin?

Focalin has active ingredients of dexmethylphenidate hydrochloride. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 4,781 Focalin users. Check the latest studies of Focalin.

What is Periactin?

Periactin has active ingredients of cyproheptadine hydrochloride. It is often used in migraine. eHealthMe is studying from 2,214 Periactin users. Check the latest studies of Periactin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

13 people who take Focalin and Periactin together, and have interactions are studied.

Focalin and Periactin drug interactions.

What are the common drug interactions of Focalin and Periactin, by gender? *:

female:

Nausea (feeling of having an urge to vomit)
Cough
Dyspnoea (difficult or laboured respiration)
Headache (pain in head)
Pneumonia
Sinusitis (inflammation of sinus)
Vomiting
Anxiety
Disturbance in attention
Irritability

male:

Irritability
Abnormal behaviour
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Cough
Crepitations (noises are produced by the rubbing of parts one against the other)
Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
Cystic fibrosis (disease of the secretary glands)
Depressed mood
Dizziness
Drug ineffective

What are the common drug interactions of Focalin and Periactin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Abnormal behaviour
Confusional state
Petit mal epilepsy (absence seizure)
Pupillary reflex impaired
Staring (a prolonged gaze or fixed look)
Unresponsive to verbal stimuli
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Dysarthria (speech disorder)
Grand mal convulsion (a type of generalized seizure that affects the entire brain)
Hypotonia (low muscle tone)

10-19:

Aggression
Agitation (state of anxiety or nervous excitement)
Anger
Blood pressure diastolic decreased
Blood prolactin increased
Breath sounds
Clubbing (deformity of the fingers and fingernails)
Cough
Crepitations (noises are produced by the rubbing of parts one against the other)
Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

Adrenoleukodystrophy (loss of myelin surrounding nerve cells in the brain and progressive adrenal gland): 3 people, 23.08%
Renal Cell Carcinoma (a kidney cancer): 1 person, 7.69%
Affective Disorder (mental disorder): 1 person, 7.69%
Aggression: 1 person, 7.69%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 1 person, 7.69%
Bronchial Disorder: 1 person, 7.69%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 1 person, 7.69%
Constipation: 1 person, 7.69%
Cystic Fibrosis (disease of the secretary glands): 1 person, 7.69%
Vitamin E Deficiency: 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

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