Focalin and Zofran drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Focalin (dexmethylphenidate hydrochloride) and Zofran (ondansetron hydrochloride). Common drug interactions include hypoaesthesia among females and anaphylactic reaction among males.

The phase IV clinical study analyzes what interactions people have when they take Focalin and Zofran. It is created by eHealthMe based on reports of 58 people who take the same drugs from the FDA, and is updated regularly.

What is Focalin?

Focalin has active ingredients of dexmethylphenidate hydrochloride. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 4,781 Focalin users. Check the latest studies of Focalin.

What is Zofran?

Zofran has active ingredients of ondansetron hydrochloride. It is often used in nausea. eHealthMe is studying from 94,987 Zofran users. Check the latest studies of Zofran.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 17, 2026

58 people who take Focalin and Zofran together, and have interactions are studied.

What are the common drug interactions of Focalin and Zofran, by gender? *:

female:

Hypoaesthesia (reduced sense of touch or sensation)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Immune system disorder
Impaired healing
Impulsive behaviour
Influenza
Influenza like illness
Insomnia (sleeplessness)
Parathyroid disorder
Fatigue (feeling of tiredness)

male:

Anaphylactic reaction (serious allergic reaction)
Asthenia (weakness)
Decreased appetite
Depression
Fatigue (feeling of tiredness)
Growth retardation (delayed growth)
Infection
Injury
Migraine (headache)
Muscular weakness (muscle weakness)

What are the common drug interactions of Focalin and Zofran, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Drug ineffective

10-19:

Abasia (inability to walk)
Anxiety
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chest pain
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Drug ineffective
Dyspnoea (difficult or laboured respiration)
Emotional distress
General physical health deterioration (weak health status)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)

20-29:

Overdose
Somnolence (a state of near-sleep, a strong desire for sleep)
Tic (a sudden, repetitive, nonrhythmic motor movement or vocalization involving discrete muscle groups)
Abdominal pain
Abdominal pain upper
Biliary colic
Cholecystitis chronic (long lasting infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Cholesterosis (abnormal deposition of cholesterol in tissues)
Diarrhoea

30-39:

n/a

40-49:

Pneumonia
Adverse drug reaction
Chest pain
Dry mouth
Fatigue (feeling of tiredness)
Gait disturbance
Glucose tolerance impaired (blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis)
Hemiparesis (weakness on one side of the body)
Hypoaesthesia (reduced sense of touch or sensation)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)

50-59:

Fatigue (feeling of tiredness)
Ankle fracture
Back pain
Fall
Intervertebral disc disorder (spinal disc disorder)
Parathyroid disorder
Somnambulism (sleep walking)
Alopecia (absence of hair from areas of the body)
Blood calcium increased
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)

60+:

Arthritis (form of joint disorder that involves inflammation of one or more joints)
Cardiac failure congestive
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Therapeutic response unexpected
Colitis (inflammation of colon)
Confusional state
Constipation
Disturbance in attention
Drug ineffective
Headache (pain in head)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 30 people, 51.72%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 10 people, 17.24%
Migraine (headache): 6 people, 10.34%
Fibromyalgia (a long-term condition which causes pain all over the body): 5 people, 8.62%
Drowsiness: 5 people, 8.62%
Depression: 5 people, 8.62%
Gallstones (stone formation by bile component): 4 people, 6.90%
Blood Testosterone Decreased: 4 people, 6.90%
Oedema Peripheral (superficial swelling): 3 people, 5.17%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 5.17%

* Approximation only. Some reports may have incomplete information.

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