Folacin and Cordarone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Folacin (folic acid) and Cordarone (amiodarone hydrochloride). Common drug interactions include nodal rhythm among females and pleural effusion among males.

The phase IV clinical study analyzes what interactions people have when they take Folacin and Cordarone. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Folacin?

Folacin has active ingredients of folic acid. eHealthMe is studying from 1,350 Folacin users. Check the latest studies of Folacin.

What is Cordarone?

Cordarone has active ingredients of amiodarone hydrochloride. It is often used in atrial fibrillation/flutter. eHealthMe is studying from 22,776 Cordarone users. Check the latest studies of Cordarone.



On Jul, 11, 2026

13 people who take Folacin and Cordarone together, and have interactions are studied.

Folacin and Cordarone drug interactions.

What are the common drug interactions of Folacin and Cordarone, by gender? *:

female:

  1. Nodal rhythm (40-50 beats per minute)
  2. Disorientation (disability in which the senses of time, direction, and recognition of people and places)
  3. Hallucination (an experience involving the perception of something not present)
  4. Sleep terror (felling of terror in sleep)
  5. Thyroid disorder (thyroid diseases)

male:

  1. Pleural effusion (water on the lungs)
  2. Application site erythema (redness of the skin at application site)
  3. Hand deformity
  4. Hypertrophy (increase in the volume of an organ or tissue due to the enlargement of its component cells)
  5. Immunodeficiency
  6. Injection site swelling
  7. Joint range of motion decreased (disease of joint movement)
  8. Joint swelling
  9. Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
  10. Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)

What are the common drug interactions of Folacin and Cordarone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)

50-59:

  1. Atelectasis (partial or complete collapse of the lung)
  2. Breath sounds
  3. Dactylitis (dactylitis or sausage digit is inflammation of an entire digit (a finger or toe), and can be painful)
  4. Decreased appetite
  5. Grip strength decreased
  6. Hand deformity
  7. Hypertrophy (increase in the volume of an organ or tissue due to the enlargement of its component cells)
  8. Immunodeficiency
  9. Injection site swelling
  10. Joint range of motion decreased (disease of joint movement)

60+:

  1. Nodal rhythm (40-50 beats per minute)
  2. Cryptogenic organizing pneumonia (small airways (bronchioles) and air exchange sac (alveoli) become inflamed with connective tissue)
  3. Disorientation (disability in which the senses of time, direction, and recognition of people and places)
  4. Hallucination (an experience involving the perception of something not present)
  5. Hypotension (abnormally low blood pressure)
  6. Pneumonia chlamydial (pneumonia that can be caused by various types of the bacteria known as chlamydia)
  7. Sleep terror (felling of terror in sleep)
  8. Thyroid disorder (thyroid diseases)

What are the existing conditions these people have? *

  1. Psoriasis (immune-mediated disease that affects the skin): 3 people, 23.08%
  2. Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 2 people, 15.38%
  3. High Blood Pressure: 2 people, 15.38%
  4. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 7.69%
  5. Pain In Extremity: 1 person, 7.69%
  6. Lymphoma (cancer that begins in immune system cells): 1 person, 7.69%
  7. Liver Disorder (liver diseases): 1 person, 7.69%
  8. Itching: 1 person, 7.69%
  9. Insomnia (sleeplessness): 1 person, 7.69%
  10. Gout (uric acid crystals building up in the body): 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Folacin and Cordarone:

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Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Folacin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Cordarone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Folacin and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Cordarone and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on folic acid and amiodarone hydrochloride (the active ingredients of Folacin and Cordarone, respectively), and Folacin and Cordarone (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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