Folate and Linzess drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Folate (folic acid) and Linzess (linaclotide). Common drug interactions include somnolence among females and hypersomnia among males.

The phase IV clinical study analyzes what interactions people have when they take Folate and Linzess. It is created by eHealthMe based on reports of 38 people who take the same drugs from the FDA, and is updated regularly.

What is Folate?

Folate has active ingredients of folic acid. It is often used in rheumatoid arthritis. eHealthMe is studying from 6,546 Folate users. Check the latest studies of Folate.

What is Linzess?

Linzess has active ingredients of linaclotide. It is often used in constipation. eHealthMe is studying from 24,086 Linzess users. Check the latest studies of Linzess.

On Jul, 16, 2026

38 people who take Folate and Linzess together, and have interactions are studied.

What are the common drug interactions of Folate and Linzess, by gender? *:

female:

Somnolence (a state of near-sleep, a strong desire for sleep)
Subcutaneous abscess
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Therapeutic response unexpected
Type 2 diabetes mellitus
Vomiting
Weight fluctuation
Gait disturbance
Pain
Hyperhidrosis (abnormally increased sweating)

male:

Hypersomnia (excessive daytime sleepiness (eds))
Pain
Injection site erosion
Injection site extravasation (flow of (blood or lymph) from injection site)
Injection site induration
Injection site pain
Pneumonia
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Respiratory disorder (respiratory disease)
Wound

What are the common drug interactions of Folate and Linzess, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Injection site bruising
Injection site erosion
Injection site extravasation (flow of (blood or lymph) from injection site)
Injection site induration
Injection site pain
Hyperhidrosis (abnormally increased sweating)
Sleep disorder
Somnolence (a state of near-sleep, a strong desire for sleep)

30-39:

n/a

40-49:

Breast cancer
Cardiac failure congestive
Cataract (clouding of the lens inside the eye)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Facial paralysis (loss of function of face muscle)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure)
Neuropathy peripheral (surface nerve damage)
Pleural effusion (water on the lungs)

50-59:

Gait disturbance
Pain
Hyperhidrosis (abnormally increased sweating)
Insomnia (sleeplessness)
Tremor (trembling or shaking movements in one or more parts of your body)
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Back pain
Depression

60+:

Chronic kidney disease
Hypersomnia (excessive daytime sleepiness (eds))
Blood potassium decreased
Blood testosterone decreased
Cardiac failure congestive
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Diarrhoea
Dysphagia (a condition in which swallowing is difficult or painful)
Fatigue (feeling of tiredness)
Headache (pain in head)

What are the existing conditions these people have? *

Irritable Bowel Syndrome: 9 people, 23.68%
Pain: 8 people, 21.05%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 8 people, 21.05%
High Blood Cholesterol: 7 people, 18.42%
Hypersensitivity: 6 people, 15.79%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 6 people, 15.79%
Nausea (feeling of having an urge to vomit): 6 people, 15.79%
Headache (pain in head): 6 people, 15.79%
Cardiac Disorder: 5 people, 13.16%
Fibromyalgia (a long-term condition which causes pain all over the body): 5 people, 13.16%

* Approximation only. Some reports may have incomplete information.

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