Folate and Premarin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Folate (folic acid) and Premarin (estrogens, conjugated). Common drug interactions include tooth disorder among females and dysphagia among males.

The phase IV clinical study analyzes what interactions people have when they take Folate and Premarin. It is created by eHealthMe based on reports of 39 people who take the same drugs from the FDA, and is updated regularly.

What is Folate?

Folate has active ingredients of folic acid. It is often used in rheumatoid arthritis. eHealthMe is studying from 6,546 Folate users. Check the latest studies of Folate.

What is Premarin?

Premarin has active ingredients of estrogens, conjugated. It is often used in hormone replacement therapy. eHealthMe is studying from 99,630 Premarin users. Check the latest studies of Premarin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

39 people who take Folate and Premarin together, and have interactions are studied.

What are the common drug interactions of Folate and Premarin, by gender? *:

female:

Tooth disorder (tooth disease)
Visual impairment
Anaemia (lack of blood)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Pain
Skin papilloma (a general medical term for a tumour of the skin or mucous membrane with finger-like projections)
Bone disorder
Colonic polyp (extra part of colon tissue grow in intestine)
Decreased interest
Dysgeusia (disorder of the sense of taste)

male:

Dysphagia (a condition in which swallowing is difficult or painful)
Insomnia (sleeplessness)
Bone density increased
Bone disorder
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Calcinosis (calcium deposits in any soft tissue)
Cardiac arrest
Carotid artery stenosis (narrowing of carotid artery)
Cellulitis (infection under the skin)
Cerebral atrophy (decrement in size of brain)

What are the common drug interactions of Folate and Premarin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Pain
Actinic keratosis (skin disease due to sun exposure)
Adenomyosis (presence of ectopic glandular tissue found in muscle)
Anaemia (lack of blood)
Anxiety
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Balance disorder
Bone density increased
Bone disorder
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)

20-29:

n/a

30-39:

n/a

40-49:

Supraventricular extrasystoles (premature electrical impulse in the heart, generated above the level of the ventricle)
Adverse event
Dysphagia (a condition in which swallowing is difficult or painful)
Dysphonia (speech disorder attributable to a disorder of phonation)
Fatigue (feeling of tiredness)
Gait disturbance
Insomnia (sleeplessness)
Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)
Muscular weakness (muscle weakness)
Pain in extremity

50-59:

Anaemia (lack of blood)
Arthralgia (joint pain)
Aspartate aminotransferase increased
Atelectasis (partial or complete collapse of the lung)
Atrophic vulvovaginitis (inflammation of the vulva)
Bilirubin conjugated increased
Blood alkaline phosphatase increased
Blood bilirubin increased
Blood cholesterol increased
Blood pressure increased

60+:

Anxiety
Fall
Dysgeusia (disorder of the sense of taste)
Endometrial hyperplasia (enlargement of uterus wall)
Femur fracture
Foot deformity (functional disability of foot)
General physical health deterioration (weak health status)
Haematoma (collection of blood outside the blood vessels)
Haematuria (presence of blood in urine)
Hyperkeratosis (thickening of the outer layer of the skin)

What are the existing conditions these people have? *

High Blood Pressure: 5 people, 12.82%
Pain: 4 people, 10.26%
Depression: 4 people, 10.26%
Sleep Disorder: 4 people, 10.26%
Stress And Anxiety: 3 people, 7.69%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 7.69%
Chest Pain: 3 people, 7.69%
Constipation: 3 people, 7.69%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 7.69%
Muscle Aches (muscle pain): 3 people, 7.69%

* Approximation only. Some reports may have incomplete information.

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