Fragmin and Opsumit drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Fragmin (dalteparin sodium) and Opsumit (macitentan). Common drug interactions include pulmonary alveolar haemorrhage among females.

The phase IV clinical study analyzes what interactions people have when they take Fragmin and Opsumit. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Fragmin?

Fragmin has active ingredients of dalteparin sodium. It is often used in deep venous thrombosis. eHealthMe is studying from 11,999 Fragmin users. Check the latest studies of Fragmin.

What is Opsumit?

Opsumit has active ingredients of macitentan. eHealthMe is studying from 67,926 Opsumit users. Check the latest studies of Opsumit.

On Jul, 26, 2026

17 people who take Fragmin and Opsumit together, and have interactions are studied.

What are the common drug interactions of Fragmin and Opsumit, by gender? *:

female:

Pulmonary alveolar haemorrhage (acute bleeding)
Abdominal distension
Constipation
Haematocrit decreased
Haemoglobin decreased
Haemolytic anaemia (anaemia due to haemolysis)
Haemorrhagic diathesis (bleeding tendency)
Hypertension (high blood pressure)
Intra-abdominal haemorrhage (intra-abdominal bleeding)
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)

male:

n/a

What are the common drug interactions of Fragmin and Opsumit, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Pulmonary alveolar haemorrhage (acute bleeding)
Abdominal distension
Activated partial thromboplastin time prolonged
Alanine aminotransferase increased
Aspartate aminotransferase increased
Atelectasis (partial or complete collapse of the lung)
Bacillus infection
Blood alkaline phosphatase increased
Blood bilirubin increased
Constipation

30-39:

n/a

40-49:

Abdominal distension
Abdominal pain
Ascites (accumulation of fluid in the abdominal cavity)
Confusional state
Eye swelling
Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure)
Peripheral swelling
Platelet count decreased

50-59:

Back pain
Blood pressure increased
Chills (felling of cold)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Cough
Dizziness
Fall
Feeling hot
Fracture
Gait disturbance

60+:

Anaemia (lack of blood)
Gastric antral vascular ectasia (blood vessels in the lining of the stomach become fragile and become prone to rupture and bleeding)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)
Disease progression
Malignant neoplasm progression (cancer tumour came back)

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 13 people, 76.47%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 4 people, 23.53%
Lung Disorder (lung disease): 3 people, 17.65%
Cardiac Failure: 3 people, 17.65%
Dry Eyes (lack of adequate tears): 3 people, 17.65%
Gastrointestinal Disorder (functional problems of gastrointestinal tract): 3 people, 17.65%
Hyperkalemia (damage to or disease of the kidney): 3 people, 17.65%
Hypokalemia (low potassium): 3 people, 17.65%
Afterbirth Pain: 3 people, 17.65%
Promotion Of Peripheral Circulation: 3 people, 17.65%

* Approximation only. Some reports may have incomplete information.

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