Fragmin and Votrient drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Fragmin (dalteparin sodium) and Votrient (pazopanib hydrochloride). Common drug interactions include hypertension among females and confusional state among males.

The phase IV clinical study analyzes what interactions people have when they take Fragmin and Votrient. It is created by eHealthMe based on reports of 25 people who take the same drugs from the FDA, and is updated regularly.

What is Fragmin?

Fragmin has active ingredients of dalteparin sodium. It is often used in deep venous thrombosis. eHealthMe is studying from 11,999 Fragmin users. Check the latest studies of Fragmin.

What is Votrient?

Votrient has active ingredients of pazopanib hydrochloride. It is often used in metastatic renal cell carcinoma. eHealthMe is studying from 25,347 Votrient users. Check the latest studies of Votrient.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

25 people who take Fragmin and Votrient together, and have interactions are studied.

What are the common drug interactions of Fragmin and Votrient, by gender? *:

female:

Hypertension (high blood pressure)
Inflammatory bowel disease
Irritable bowel syndrome
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Lip dry
Malignant neoplasm progression (cancer tumour came back)
Metastases to central nervous system (cancer spreads to central nervous system)
Metastases to lung (cancer spreads to lung)
Pain
Polyp

male:

Confusional state
Malignant neoplasm progression (cancer tumour came back)
Urticaria (rash of round, red welts on the skin that itch intensely)
Vomiting
Acute coronary syndrome (acute chest pain and other symptoms that happen because the heart does not get blood)
Aortic valve incompetence
Atrial thrombosis (blood clot that develops in an artery)
Back pain
Blood pressure decreased
Blood pressure increased

What are the common drug interactions of Fragmin and Votrient, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Blood pressure increased
Bundle branch block (disruption in the normal flow of electrical pulses that drive the heart beat)
Cardiac failure
Chest pain
Death
Dilatation ventricular
Dysphagia (a condition in which swallowing is difficult or painful)
Dyspnoea (difficult or laboured respiration)
Ejection fraction decreased (systolic heart failure)
Electrocardiogram t wave inversion

30-39:

Atrial thrombosis (blood clot that develops in an artery)
Burning sensation
Constipation
Disease progression
Dry mouth
Dysgeusia (disorder of the sense of taste)
Hypoaesthesia (reduced sense of touch or sensation)
Hypoaesthesia teeth (reduced sense of touch or sensation)
Nail discolouration (change in nail colour)
Oedema peripheral (superficial swelling)

40-49:

Duodenal fistula
Malignant neoplasm progression (cancer tumour came back)
Sepsis (a severe blood infection that can lead to organ failure and death)
Upper gastrointestinal haemorrhage (upper gastrointestinal bleeding)

50-59:

Confusional state
Infection
Lethargy (tiredness)
Malignant neoplasm progression (cancer tumour came back)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Blood pressure decreased
Brain neoplasm (tumour of brain)
Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)
Chronic kidney disease
Death

60+:

Death
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Confusional state
Decreased appetite
Fatigue (feeling of tiredness)
Headache (pain in head)
Petechiae (a small red or purple spot caused by bleeding into the skin)
Thrombosis (formation of a blood clot inside a blood vessel)
Urticaria (rash of round, red welts on the skin that itch intensely)
Vomiting

What are the existing conditions these people have? *

Renal Cell Carcinoma (a kidney cancer): 4 people, 16.00%
Renal Cancer Metastatic (cancer of kidney spreads to other part): 4 people, 16.00%
Pulmonary Embolism (blockage of the main artery of the lung): 4 people, 16.00%
Lung Neoplasm Malignant (cancer tumour of lung): 4 people, 16.00%
Sarcoma (rare cancers that develop in the muscle, bone, nerves, cartilage, tendons, blood vessels and the fatty and fibrous tissues): 3 people, 12.00%
Thrombosis (formation of a blood clot inside a blood vessel): 2 people, 8.00%
Neoplasm Malignant (cancer tumour): 2 people, 8.00%
Nausea (feeling of having an urge to vomit): 2 people, 8.00%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 2 people, 8.00%

* Approximation only. Some reports may have incomplete information.

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