Frova and Fioricet drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Frova (frovatriptan succinate) and Fioricet (acetaminophen; butalbital; caffeine). Common drug interactions include fatigue among females and chest discomfort among males.

The phase IV clinical study analyzes what interactions people have when they take Frova and Fioricet. It is created by eHealthMe based on reports of 41 people who take the same drugs from the FDA, and is updated regularly.

What is Frova?

Frova has active ingredients of frovatriptan succinate. It is often used in migraine. eHealthMe is studying from 2,100 Frova users. Check the latest studies of Frova.

What is Fioricet?

Fioricet has active ingredients of acetaminophen; butalbital; caffeine. It is often used in migraine. eHealthMe is studying from 12,423 Fioricet users. Check the latest studies of Fioricet.

On Jul, 12, 2026

41 people who take Frova and Fioricet together, and have interactions are studied.

What are the common drug interactions of Frova and Fioricet, by gender? *:

female:

Fatigue (feeling of tiredness)
Hypertension (high blood pressure)
Road traffic accident
Dyspnoea (difficult or laboured respiration)
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Muscular weakness (muscle weakness)
Renal impairment (severely reduced kidney function)
Suicidal ideation
Chest pain
Gastric ulcer haemorrhage (bleeding ulcer of stomach)

male:

Chest discomfort
Fatigue (feeling of tiredness)
Malaise (a feeling of general discomfort or uneasiness)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Myalgia (muscle pain)
Nausea (feeling of having an urge to vomit)
Pyrexia (fever)

What are the common drug interactions of Frova and Fioricet, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Adrenal mass
Derealisation
Fatigue (feeling of tiredness)
Lethargy (tiredness)
Polycystic ovaries (cysts in the ovaries that occurs when the follicle stops developing)
Visual impairment
Abdominal discomfort
Adrenal adenoma (benign tumour of the glandular type (adenoma) in the adrenal gland)
Adverse drug reaction
Anxiety

30-39:

Chest pain
Dyspnoea (difficult or laboured respiration)
Nausea (feeling of having an urge to vomit)
Dizziness
Drug ineffective
Intervertebral disc degeneration (spinal disc degeneration)
Oedema peripheral (superficial swelling)
Pain in extremity
Vomiting
Abdominal pain

40-49:

Stress urinary incontinence (leak urine with things like coughing, sneezing or exercise)
Urinary incontinence (inability to control the flow of urine and involuntary urination)
Abdominal pain lower
Adenoma benign (non-cancerous tumour -secreting)
Affect lability (emotional incontinence)
Breast inflammation
Breast mass
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Drug tolerance increased
Dyspepsia (indigestion)

50-59:

Speech disorder
Diabetes mellitus non-insulin-dependent
Meniscus lesion (lesion of a crescent-shaped piece of cartilage between the femur and the tibia)
Muscle spasms (muscle contraction)
Type 2 diabetes mellitus
Anaemia (lack of blood)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Burning sensation
Fatigue (feeling of tiredness)
Influenza like illness

60+:

Drug administration error
Therapeutic response unexpected

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 12 people, 29.27%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 7 people, 17.07%
Pain: 5 people, 12.20%
Headache (pain in head): 5 people, 12.20%
Stress And Anxiety: 4 people, 9.76%
Oedema Peripheral (superficial swelling): 4 people, 9.76%
High Blood Pressure: 4 people, 9.76%
Gout (uric acid crystals building up in the body): 4 people, 9.76%
Back Pain: 4 people, 9.76%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 4 people, 9.76%

* Approximation only. Some reports may have incomplete information.

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